In medical practice, a high optical resolution of medical devices used to visualize cancerous tumors [1] and cells [2] and in photodynamic therapy [3,4] is an extremely important factor. High resolution is determined by the small width of the corresponding optical bands, which, in turn, is determined by the rational use of physical phenomena on which the creation of medical devices is based. The ideal physical phenomena here would be any optical resonances that have a small width and high intensity. Such a resonance is the Egorov nano-resonance [5‒8]. Egorov’s nano-resonance is one of the important consequences of the new physical theory — quantum ‒classical mechanics [5,6,9,10]. As is known, in standard quantum mechanics, a certain statistical characteristic of a microparticle (wave function) obeys a certain dynamic equation (Schrӧdinger’s equation). This statistical characteristic is an innate property of an individual microparticle. In quantum‒classical mechanics, in addition to this innate statistical characteristic of an individual microparticle, innate chaos appears in the interaction of microparticles. This chaos is called dozy chaos. In quantum mechanics, molecular (electron‒phonon) transitions are singular, and they are damped by dozy chaos in quantum‒classical mechanics [10]. Dozy chaos is present only in the transient state of electron‒phonon transitions, and it can be neglected in the initial and final adiabatic states of the transitions. Egorov’s nano-resonance is a resonance in nano-scale molecular systems between the extended motion of an electron and the motion of reorganization of the environmental nuclei in the process of electron‒phonon transitions under conditions of weak dozy chaos [8]. Based on Egorov’s nano-resonance, the resonant nature of the change in the shape of optical absorption bands in the series of polymethine dyes, in which the length of the polymethine chain changes, as well as the narrow and intense J-band of well-known J-aggregates are explained [5‒9,11]. In the framework of quantum–classical mechanics, on the basis of Egorov nano-resonance and the law of conservation of energy, an explanation is given for the strong detuning of the resonance and the associated significant parasitic transformation of the shape of the resonant optical absorption band as a result of the transition from linear to nonlinear, two-photon absorption in polymethine dyes in solutions (in selenopyrylium-terminated polymethine dye Se-3C dissolved in chloroform) [12‒14]. Based on this explanation and model band shapes of the theoretical fit to the experimental optical bands [12], the conditions for reconstructing the resonance shape of the band for two-photon absorption and its redshift are predicted [14]. The creation of quantum–classical mechanics of nonlinear optical processes in polymethine dyes will further serve as a theoretical basis for the study of nonlinear optical processes also in more complex organic systems, which are promising for applications in three-dimensional (3D) fluorescence imaging, lasing up-conversion, optical power limitation, photodynamic therapy, 3D optical data storage and so on (see [14] and refs 57‒60 therein).

Titanium alloy (Ti-6Al-4V) has been widely used in medical field due to its good biocompatibility and machinability. However, Ti-6Al-4V lacks antibacterial ability, which can be easy to lead the surgical infection by bacteria. At the same time, the release of the toxic ions such as Al or V in Ti-6Al-4V to the human body under the physiological environment is also easy to cause harm to the human body. Therefore, in order to solve the above problems, this study first used magnetron sputtering technique to prepare TiN-Cu composite coatings on the surface of Ti-6Al-4V, which is expected to take advantage of Cu's antibacterial properties to achieve long-term antibacterial effects while preventing the release of toxic ions. Second, in order to enhance cell adhesion of the TiN-Cu composite coatings, plasma immersion ion implantation (PIII) was used to implant Mg ions into the surface of the composite coatings respectively. A series of measurements (such as XRD, XPS, SEM, etc.) were used to analyze the structure, composition and mechanical properties of TiN-Cu composite coatings before and after implantation with different ions. L929 cells and Mc3t3-e1 cells were used to analyze the cell proliferation and adhesion on the sample surfaces. The survival of Escherichia coli by using the coating plate method. The results showed that the surface of Mg+ implanted TiN-Cu composite film had the best antibacterial property and cell proliferation ability with the highest protein adsorption ability. Cu trapped electrons on the bacteria's surface and destroyed their membranes. In addition, the bonding of Cu and respiratory enzymes in the bacteria also caused bacterial dysfunction. The implanted Mg+ on the surface stimulated protein adsorption, the cell adhesion and proliferation.

Exposure to mutant and neglected disease resistant pathogen strains is high and presents a significant threat to public health, peace and economic mobility. The microbe outruns the R&D time-line for a new generation of drug. The microbe has changed its genome to outwit the therapy. Biological warfare poses a significant threat to a human population, operations of security personnel and emergency response specialists. Antibiotics and vaccine resistance renders the efficacy and potency of the current crop of antibiotics and treatments useless and expensive. 

Such challenges need to be significantly remedied with new solutions. A moving target pathogen can be eliminated via electrodynamic treatment of an infection in a human being. A move to do away with antibiotics is in sight. Electrodynamics can eliminate the microbe independent of its mutant strategies. The electrodynamic option for fast remedy is based on deeper insights on the definitions of terms thought of as understood in Physics. This paper will define the paradigm shift in understanding of everyday terms such as temperature, Ohm’s Law, electric charge, mass, frequency and wavelength.

The electrodynamic therapy to rid pathogens is a direct result of interdisciplinary research work in physics, chemistry, pharmacy and medicine. The rationale of this original research is in the realm of empirical biophysics.

The goals are specific, and the foundation work has been completed.

The results of this work will have worldwide impact since the diseases treated by this new regimen will help millions by destroying pathogens often identified at autopsy.

In this keynote talk, I will give an overview of recent progress from my lab on development of nanoengineered surfaces and materials that benefit many areas of application. Over the years, we developed a range plasma based methods, know-how and expertise which allow us to control that entire spectrum of materials surface properties, including chemical, physical, mechanical and topographical. The main focus of our research is on the surface modification of medical devices and biomaterials with the purpose to improve healthcare outcomes in areas such as prevention of infection, modulation of inflammation, cell therapies, tissue engineering, and medical diagnostics. I will discuss our newest discoveries and technologies, some of which have been translated onto commercial devices in collaboration with industry. However, our surface modification technologies are not limited to healthcare and medicine. We have demonstrated the utility of nanoengineered plasma polymers for solving problems in other areas such as environmental science and remediation, heath sustainability, water treatment and even wine making. In will present the engineering and chemical concepts underpinning “nanoengineering of plasma polymers” and give a range of examples of application of our technologies in various fields.

The new fundamental physical theory, quantum–classical mechanics (QCM), takes into account the chaotic dynamics of the transient state (TS) in electron-phonon transitions [1–3]. In the case of strong transient (dozy) chaos QCM gives the same result as the standard Franck–Condon picture of electronic-vibrational transitions [4]. Dozy chaos (DC) provides the convergence of a series of time-dependent perturbation theory which is absent in the standard quantum picture [2]. In the case of weak DC, an important result of QCM is the Egorov nano-resonance (Enr), which is associated with the appearance of a pronounced regular dynamics against the background of DC and which explains the nature of the narrow and intense optical J-band of the well-known J-aggregates [5]. The discovery of QCM and Enr opens up the possibility of creating optical spectroscopy of extended molecular systems, in which, along with DC, the effects of regular dynamics in TS are significant. DC in TS is provoked by a light electron “in order” to ensure the reorganization of a very heavy nuclear subsystem, and hence the very possibility of electronic-vibrational transitions. This organizing property of the electron undoubtedly plays an enormous role in biological processes. The next stage in the development of QCM can be to complicate the system by organizing various aggregates, where the “elementary cell” in the theory and/or the starting point for the development of the theory will be the already solved problem of elementary electron transfers in QCM [6]. The purpose of such complication and enumeration of all possible variants of aggregation will be to find the “molecule of life”, that is, the rather complex, but “minimal” structural configurations, in which elements of self-organization, both structural and dynamic, observed in theoretical optical spectra, are clearly manifested. The “atom of life” here is the electron itself which provokes DC. Thus, through the increasing complexity of the design of molecular systems, QCM opens up great prospects for the search and study of the simplest forms of life organization and related phenomena. For example, a new kind of possible materials, “living materials”, can provide us with much more comfortable living conditions [6]. Advanced artificial living beings (ALBs), created based on targeted molecular systems design and engineering, and, for example, radiation-resistant, will be able to greatly help humanity in future space exploration [6]. On planet Earth, diverse communities of ALBs will represent a virtually unlimited source of skilled labor in all areas of human activity and entirely under human control. Among other things, ALBs will give impetus to the creation of the most effective form of socio–economic and moral organization of human civilization (see [6] and references therein), which is unattainable under the currently existing egoistic paradigm of human society [7], which arose as a result of a long evolutionary process.

Inflammatory state and immunity are the two patient conditions that need to be addressed when infectious disease hits a population or when co-infection exists in chronic disease conditions. The Magellan Therapeutic Inc. platform addresses these two patient conditions. The method employs replenishing diminished levels of a key component of the lectin pathway by cell and gene therapy. The lectin pathway is responsible for immunity as well as inflammation. Every person on Earth has probably taken a small molecule or an injection of a steroid for inflammation or antibiotics to treat infection. The waste generated from the entire cycle from disposable plastics, gowns, masks, to biowaste from liquid biopsy, patient sputum, fecal and urine is a neglected aspect of disease burden. Moreover, the cost of generating potable water from contaminants ranging from drug excretion in sewage to disturbance in soil and water pH to drug resistant pathogen mutants is largely overlooked. A discussion on nipping these issues in the bud from bench to patient is presented. The dots are connected via simple diagrams for a snapshot of the bigger picture. Solutions to the crisis are provided for debate and implementation irrespective of political viewpoints. The goal post does not move. An alternative model in new trade free parks is proposed with sustained nondilutive funding. The goal is human flourishing.