ORALS

SESSION: OxidativeTuePM1-R1	Ozawa International Symposium (3rd Intl. Symp. on Oxidative Stress for Sustainable Development of Human Beings)
Tue. 28 Nov. 2023 / Room: Dreams 1
Session Chairs: Christian Andre Amatore; Koji Fukui; Session Monitor: TBA

14:55: [OxidativeTuePM107] OS
TWENDEE MT CONTROL IMPROVES COGNITIVE FUNCTION IN AGED MICE
Koji Fukui¹ ; Fuhua Yang² ; Yugo Kato³ ; Shuya Yuzawa⁴ ; Ayuta Kishimoto⁴ ; Takuma Hara⁴ ; Yuki Kanome⁴ ; Yoshiaki Harakawa² ; Toshikazu Yoshikawa⁵ ; Haruhiko Inufusa² ; ¹Shibaura Inst. of Technology, Saitama, Japan; ²Gifu University, Gifu, Japan; ³Tottori University, Yonago, Japan; ⁴Shibaura Institute of Technology, Saitama, Japan; ⁵Louis Pasteur Center, Kyoto, Japan;
Paper Id: 153 [Abstract]

Aging is a universal degenerative disease. Aging is classified into physiological and pathological. The progression rate of pathological aging varies among individuals, and reactive oxygen species is deeply involved in pathological aging. One of the most serious phenomena during aging is dementia. To prevent age-related neurodegenerative disorders, treatment with antioxidants is effective. Twendee Mt Control which is a supplement contains 15 substances and anyone can buy it. However, the detailed scientific evidence is not enough. In the present study, we treated combination supplement to aged mice, and measured their cognitive and motor functions. We purchased aged mice and treated them with Twendee Mt Control for one month. Cognitive and motor functions were measured by the Morris Water maze and rota-rod test [1]. Normal aged mice had significantly reduced learning ability. Treatment with Twendee Mt Control improved significantly. Twendee Mt Control significantly improved time-to-fall scores on the rota-rod test. Finally, treatment with Twendee Mt Control showed a high training effect in the treadmill test. These results indicated that treatment with Twendee Mt Control has a potential as a powerful antioxidant supplement through protection against age-related neuronal and motor dysfunctions.  

References:
[1] [1] Fukui, K, Onodera, K, Shinkai, T, et al., Ann NY Acad Sci, 928 (2001) 169-176.