ORALS

SESSION: OxidativeTueAM-R1	Ozawa International Symposium (3rd Intl. Symp. on Oxidative Stress for Sustainable Development of Human Beings)
Tue. 28 Nov. 2023 / Room: Dreams 1
Session Chairs: Haruhiko Inufusa; Koji Fukui; Session Monitor: TBA

12:50: [OxidativeTueAM04] OS
COMBINATION SUPPLEMENT, TWENDEE X IMPROVES LEARNING DYSFUNCTION IN LONG-TERM VITAMIN E-DEFICIENT MICE
Koji Fukui¹ ; Fuhua Yang² ; Yoshiaki Harakawa² ; Toshikazu Yoshikawa³ ; Haruhiko Inufusa² ; ¹Shibaura Inst. of Technology, Saitama, Japan; ²Gifu University, Gifu, Japan; ³Louis Pasteur Center, Kyoto, Japan;
Paper Id: 154 [Abstract]

Vitamin E deficiency accelerates in vivo oxidation and is closely related to aging. Accumulation of oxidative products increases risk of developing serious disorders such as dementia and cardiovascular events [1]. Normally, our bodies maintain a balance between oxidation and reduction, but the redox balance gradually collapses as we age. To prevent oxidation, we should take supplements. The supplement market is growing year by year all over the world. One combination supplement is Twendee X, which contains 8 substances [2]. However, the detailed scientific evidence for Twendee X has not yet been elucidated. In this study, long-term vitamin E-deficient mice were fed Twendee X and measured cognitive and motor functions using the Morris water maze and rota-rod tests [3]. Vitamin E-deficient mice had significantly impaired cognitive and motor functions, learning rate was comparable to normal aged mice. Treatment with Twendee X significantly improved both dysfunctions. However, serum indices did not differ with or without Twendee X. These results indicate that Twendee X has a potential as a powerful antioxidant supplement through protection against in vitro oxidation.

References:
[1] Yoshida, N, Kato, Y, Takatsu, H, et al., Biomedicines 10 (2022) 28.
[2] Tadokoro, K, Morihara, R, Ohta, Y, et al., J Alzheimer’s Dis, 71 (2019) 1063-1069.
[3] Fukui, K, Onodera, K, Shinkai, T, et al., Ann NY Acad Sci, 928 (2001) 169-176.

SESSION: OxidativeTuePM1-R1	Ozawa International Symposium (3rd Intl. Symp. on Oxidative Stress for Sustainable Development of Human Beings)
Tue. 28 Nov. 2023 / Room: Dreams 1
Session Chairs: Christian Andre Amatore; Koji Fukui; Session Monitor: TBA

14:55: [OxidativeTuePM107] OS
TWENDEE MT CONTROL IMPROVES COGNITIVE FUNCTION IN AGED MICE
Koji Fukui¹ ; Fuhua Yang² ; Yugo Kato³ ; Shuya Yuzawa⁴ ; Ayuta Kishimoto⁴ ; Takuma Hara⁴ ; Yuki Kanome⁴ ; Yoshiaki Harakawa² ; Toshikazu Yoshikawa⁵ ; Haruhiko Inufusa² ; ¹Shibaura Inst. of Technology, Saitama, Japan; ²Gifu University, Gifu, Japan; ³Tottori University, Yonago, Japan; ⁴Shibaura Institute of Technology, Saitama, Japan; ⁵Louis Pasteur Center, Kyoto, Japan;
Paper Id: 153 [Abstract]

Aging is a universal degenerative disease. Aging is classified into physiological and pathological. The progression rate of pathological aging varies among individuals, and reactive oxygen species is deeply involved in pathological aging. One of the most serious phenomena during aging is dementia. To prevent age-related neurodegenerative disorders, treatment with antioxidants is effective. Twendee Mt Control which is a supplement contains 15 substances and anyone can buy it. However, the detailed scientific evidence is not enough. In the present study, we treated combination supplement to aged mice, and measured their cognitive and motor functions. We purchased aged mice and treated them with Twendee Mt Control for one month. Cognitive and motor functions were measured by the Morris Water maze and rota-rod test [1]. Normal aged mice had significantly reduced learning ability. Treatment with Twendee Mt Control improved significantly. Twendee Mt Control significantly improved time-to-fall scores on the rota-rod test. Finally, treatment with Twendee Mt Control showed a high training effect in the treadmill test. These results indicated that treatment with Twendee Mt Control has a potential as a powerful antioxidant supplement through protection against age-related neuronal and motor dysfunctions.  

References:
[1] [1] Fukui, K, Onodera, K, Shinkai, T, et al., Ann NY Acad Sci, 928 (2001) 169-176.