ORALS

SESSION: MedicineWedPM2-R1	2nd Intl. Symp. on Technological Innovations in Medicine for Sustainable Development
Wed. 29 Nov. 2023 / Room: Dreams 1
Session Chairs: Hans Leuenberger; Gregory Knipp; Session Monitor: TBA

16:25: [MedicineWedPM210] OL
AUGMENTED REALITY IN NEUROSURGERY: A NEW PARADIGM FOR TRAINING
Brandon Lucke-Wold¹ ; ¹University of Florida, ., United States;
Paper Id: 425 [Abstract]

Augmented reality (AR) involves the overlay of computer-generated images onto the user’s real-world visual field to modify or enhance the user’s visual experience. With respect to neurosurgery, AR integrates preoperative and intraoperative imaging data to create an enriched surgical experience that has been shown to improve surgical planning, refine neuronavigation, and reduce operation time. In addition, AR has the potential to serve as a valuable training tool for neurosurgeons in a way that minimizes patient risk while facilitating comprehensive training opportunities. The increased use of AR in neurosurgery over the past decade has led to innovative research endeavors aiming to develop novel, more efficient AR systems while also improving and refining present ones. In this review, we provide a concise overview of AR, detail current and emerging uses of AR in neurosurgery and neurosurgical training, discuss the limitations of AR, and provide future research directions. Following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), 386 articles were initially identified. Two independent reviewers (GH and AC) assessed article eligibility for inclusion, and 31 articles are included in this review. The literature search included original (retrospective and prospective) articles and case reports published in English between 2013 and 2023. AR assistance has shown promise within neuro-oncology, spinal neurosurgery, neurovascular surgery, skull-base surgery, and pediatric neurosurgery. Intraoperative use of AR was found to primarily assist with surgical planning and neuronavigation. Similarly, AR assistance for neurosurgical training focused primarily on surgical planning and neuronavigation. However, studies included in this review utilize small sample sizes and remain largely in the preliminary phase. Thus, future research must be conducted to further refine AR systems before widespread intraoperative and educational use.

SESSION: MedicineFriAM1-R1	2nd Intl. Symp. on Technological Innovations in Medicine for Sustainable Development
Fri. 1 Dec. 2023 / Room: Dreams 1
Session Chairs: Hans Leuenberger; Session Monitor: TBA

09:05: [MedicineFriAM103] OL
FOCUSED DELIVERY OF CHENOTHERAPY TO AUGMENT SURGICAL MANAGEMENT OF BRAIN TUMORS
Brandon Lucke-Wold¹ ; ¹University of Florida, ., United States;
Paper Id: 525 [Abstract]

Chemotherapy as an adjuvant therapy that has largely failed to significantly improve outcomes for aggressive brain tumors; some reasons include a weak blood brain barrier penetration and tumor heterogeneity. Recently, there has been interest in designing effective ways to deliver chemotherapy to the tumor. In this review, we discuss the mechanisms of focused chemotherapies that are currently under investigation. Nanoparticle delivery demonstrates both a superior permeability and retention. However, thus far, it has not demonstrated a therapeutic efficacy for brain tumors. Convection-enhanced delivery is an invasive, yet versatile method, which appears to have the greatest potential. Other vehicles, such as angiopep-2 decorated gold nanoparticles, polyamidoamine dendrimers, and lipid nanostructures have demonstrated efficacy through sustained release of focused chemotherapy and have either improved cell death or survival in humans or animal models. Finally, focused ultrasound is a safe and effective way to disrupt the blood brain barrier and augment other delivery methods. Clinical trials are currently underway to study the safety and efficacy of these methods in combination with standard of care.