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SYMPOSIUM and ROUND TABLE TOPICS

The following are the subjects to be treated at this international symposium:

Basics

The human immune system uses the final products of oxidative stress to protect the human body from bacterial or virus infections. However, an excess of oxidative stress is closely related to almost all diseases as well as aging. In this symposium presentations will be widely accepted related but not limited to basic research as well as practical applications on these diseases and their symptoms

1. COVID-19, virus infection, allergy
   Oxidative stress and immune activity are closely related with disease or symptoms. Allergic reaction depending on imbalance of immune system which is easy to damage by oxidative stress. AIDS infection to white blood cell resulted huge dose secretion of oxidative stress, induces immunosuppression and various diseased including malignancy. Pneumonia of COVID-19 corona virus infection is totally different from ordinary pneumonia by bacteria infection. COVID-19 pneumonia starts lower and back side of lung and CT scan shows typical interstitial pneumonia. Interstitial pneumonia is kind of allergic reaction, thus pneumonia start high blood flow area of lung and very rapidly spread to the whole lung. It is well known that interstitial pneumonia shows very high oxidative stress, damages lung tissue, and some patients shows irreversible damage on lung. Once immune systems over run, it causes fatal cytokine storm. Fatal risks of COVID-19 virus infection are high age with underline disease. Especially diabetes mellitus, obesity, heart disease, hypertension, after stroke, cancer, neurogenic disorder, dementia and so on. All these risk factors show very high oxidative stress. In other word, Risk factor of COVID-19 virus infection is oxidative stress. In human life, oxidative stress is most low at newborn, increase slowly till age 30, increase to high level at age over 70. Low oxidative stress will be one of reason why child infected COVID-19 virus usually no symptoms or no severe condition. Kawasaki disease like vasculitis in young child and cerebral infraction in mid age are reported at New York or Spain by COVID-19 infection. Oxidative stress damages vascular endothelium and inflammation of vascular wall produces thrombosis. Oxidative stress is major role in these symptoms.
2. Aging
   The level of oxidative stress in the human body is the lowest at birth and stay low up to the age of 30. This level increases after the age of 30. Very high levels of oxidative stress in the human body have been found in children that suffer from progeria, a well-known genetic disease that makes the body to age very fast and causes premature death before age of 20. As a consequence, reducing oxidative stress may prevent various disease and prolong human life as well. Mitochondria, an organelle or a specialized cell subunit that is found in every cell of the human body except red blood cells is a resource of oxidative stress that produces energy and detox of human body. As such, controlling mitochondrial functions related to aging is subject of numerous scientific researches worldwide. Aging and the quality of life are important factors for sustainable development.
3. Sleep Apnea
   Sleep Apnea, a potentially serious sleep disorder in which breathing repeatedly stops and starts, has been shown to be directly related to tragedies such as Exxon Valdez oil spill, Space Shuttle Challenger disaster or many traffic accidents. In USA, over 40 million patients suffering from Sleep Apnea are cause of direct economic losses of 15,900 million USD per year and indirect losses of 100 billion USD per year, making it a serious social risk that negatively affects sustainable development. It has been shown that humans that suffer from Sleep Apnea have high oxidative stress levels that have been positively correlated with its symptoms. As such, reducing oxidative stress is very important factor in treating Sleep Apnea patients.
4. Reproduction
   Recent research published in the international academic specialized magazine "Human Reproduction Update" gives shocking information that sperms counts in males has decreased by 52% during the last 40 years. It is known that sperm can be damaged by smoke, alcohol abuse, electromagnetic waves (cell phone), radiation, microwave, UV and diseases (diabetes, cancer). All latter factors increase oxidative stress in the human body. People are not aware that Bisphenol A used in plastics and aspartame used as a sweetener in coffees are very strong chemicals that increase oxidative stress and reduce sperm count in males. As such an effective strategy is required related to human reproduction in the view of sustainable development. Ovum is also damaged by oxidative stress. After the age 36, ovum membrane hardens and this is one of reasons of having difficult fertilization after that age. Oxidative stress also damages ovum DNA and causes an increase potential for genetic abnormalities.
5. Bacterial flora
   Recently, research on bacterial flora is an important topic in scientific research because of the facts that 60% of human immune systems depends on intestinal bacterial flora. Oxidative stress levels in humans are also effected by intestinal bacterial flora. Scientist believes that a proper control of intestinal bacterial flora may reduce oxidative stress and prevent various disease. This is because human lives coexist with a huge number of bacteria in it.
6. Cancer
   Cancer cells produce oxidative stress in the human body. Oxidative stress damages the human immune system similar to a natural killer and decreases its ability to fight cancer. An increased level of oxidative stress induces also inflammation which causes additional problems in the human body. Clinical "activities of daily living" correlate well with the amount of oxidative stress in cancer patients. As a result, targeting oxidative stress in the cancer patients is very important in the fight against cancer.
   
   Presentations are welcomed on various topics that include but will not be limited to:
   • Measuring of the oxidative stress in persons suffering from the above conditions and specifically in patients fighting cancer
   • Practical treatment with anti-oxidative stress agents of persons suffering from the above conditions and specifically in patients fighting cancer.
   • Any research or conclusion related to the above issues or alternative treatments.
   • Role of reactive species (ROS, RNS, RSS) in evolution, healthy and pathological conditions, and contemporary medicine.

ROUND TABLE DISCUSSIONS
A round table discussion open to everyone interested will be organized at a specific date and time during the symposium. It will be a platform for high level representatives of various industries, technologies, and academic disciplines to freely discuss and debate all topics of this symposium, and identify positive and efficient pathways towards sustainability in industrial practices, technologies, and research. You are cordially invited to actively participate in this symposium by submitting and presenting a paper, or by attending the round table. We look forward to meeting you in Phuket.

Main Keywords

- Oxidative Stress - Reactive Oxygen Species (ROS) - Reactive Nitrogen Species (RNS) - Reactive Sulfur Species (RSS) - Free Radicals - Hydrogen peroxide - Peroxynitrite - Nitric Oxide	- Cellular Oxidative Damage - Apotosis - Autophagy - Autophagocytosis - Endocrine-Disrupting Chemicals
- Anti-Oxidants - Antioxidant Therapeutic Options - Vitamin C - Glutathione - Tocopherol - Food Complements	- Mitochondria - Macrophages - Lymphocytes - Phagocytosis - Lysosomes
- Aging - Diabetes Type I - Cancers - Cancer Initiation - Cancer Microtissular Environment - Cancer Cells Proliferation - Auto-immune Diseases - Sex differences in autoimmune disease - Immunosuppressive Drugs - Autoimmune dysthyroidism - Chronic Inflammation - Multiple Sclerosis - Sjogren's syndrome - Scleroderma - Inflammatory Rheumatic Diseases - Rheumatoid Arthritis - Intestinal Microbiote - Crohn Disease - Inflammatory Gastrointestinal Diseases	- Brain Diseases - Neurodegenerative Diseases - Alzheimer Disease - Parkinson Disease - Brain Ischemia - Amyloid beta - Tau Protein - Cardiovascular Diseases - Myocardial Infarction - Post-Ischemic Perfusion Injury - Stroke