ORALS

SESSION: OxidativeMonAM-R1	Yoshikawa International Symposium (2nd Intl. Symp. on Oxidative Stress for Sustainable Development of Human Beings)
Mon. 28 Nov. 2022 / Room: Ballroom B
Session Chairs: Toshikazu Yoshikawa; Haruhiko Inufusa; Session Monitor: TBA

12:20: [OxidativeMonAM03] OS
The antioxidant Twendee X and cancer treatment
Naomi Okada¹ ; Fuhua Yang² ; Taku Nakashima³ ; Haruhiko Inufusa⁴ ; Toshikazu Yoshikawa⁵ ; ¹Gifu University, Gifu, Japan; ²Division of Anti-Oxidant Research, Gifu University, Gifu, Japan; ³Department of Molecular and Internal Medicine, Graduate school of Biomedical & Health sciences, Hiroshima University, Hiroshima, Japan; ⁴TIMA, Gifu, Japan; ⁵Louis Pasteur Center, Kyoto, Japan;
Paper Id: 124 [Abstract]

As examples of cancer treatment, immunotherapy is now widely recognized as a powerful cancer therapy in addition to conventional therapies such as operation, chemotherapy and radiotherapy. Although they are all effective treatments, chemotherapy and radiotherapy, which take advantage of small differences between cancer cell (tumor cell) and normal cell, damage normal cells as well as cancer cells. As a result, adverse events are almost inevitable and are often difficult to continue treatment depending on the degree. 　As these treatments are administered over months or years, physical and mental damage accumulate, leading to a decline in physical strength and immunity. These adverse events are largely due to oxidative stress. That is, the tumor itself, and reactive oxygen species (ROS) generated by treatment for it, can cause damage to various cells due to oxidative stress. And oxidative stress can cause a decline in physical strength and immunity, which leads to tumor growth and a negative spiral. Thus, suppression of oxidative stress in tumor and cancer treatment may be very effective in not only alleviating symptoms but also prolonging prognosis. Since oxidative stress-mediated mechanisms of carcinogenesis also exist, suppression of oxidative stress may help to prevent cancer. An antioxidant compound Twendee X (TWX) which composed of vitamins, amino acids, and CoQ 10 is rated as the strongest and safe antioxidant in the world by ICDD (France). Cytoprotective effects of TWX against radiation exposure were examined using murine alveolar epithelial cells (LA-4). After allowing LA-4 cells to adhere, 25ug/ml of TWX was added in the medium. The cells were irradiated with 30Gy of radiation 2 hours after the addition, and after 72 hours, the effect on cell proliferative capacity was examined. The result showed that TWX significantly inhibited the radiation-induced decrease in cell proliferative capacity. In addition, TWX can be used in single and continuous doses in both healthy and pregnant mice and also increased NK activity, which is tumor immunity. In summary, TWX not only reduced adverse events during cancer treatment but also increased tumor immunity. We believe TWX can be an aid in the treatment and prevention of cancer.

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