ORALS

SESSION: SISAMThuPM1-R3 B: Bio is beautiful	Kobe International Symposium on Science of Innovative and Sustainable Alloys and Magnets (5th Intl. Symp. on Science of Intelligent and Sustainable Advanced Materials (SISAM))
Thu Oct, 24 2019 / Room: Dr. Christian Bernard
Session Chairs: Saso Sturm; Session Monitor: TBA

14:50: [SISAMThuPM107]
Towards The Sustainability of Implantable Medical Devices
Richard Kouitat Njiwa¹ ; Pierre Bravetti² ; M'barek Taghite³ ; Gael Pierson⁴ ; ¹Institut Jean Lamour (UMR 7198 CNRS-Université de Lorraine), Nancy, France; ²Institut Jean Lamour (UMR 7198 CNRS-Uninersite de lorraine), Nancy, France; ³, Laxou, France; ⁴Institut Jean Lamour, Nancy, France;
Paper Id: 137 [Abstract]

Whether for therapeutic or aesthetic purposes, implantable medical devices have to be biocompatible and functional. Their implementation requires surgery that can be considered as a cumbersome procedure as it depends on the patient. Additionally, the osseointegration of these implantable devices has to be sustinable. Considering the example of dental implants, there are two types of implants: endosseous axial implants and supraosseous basal with lateral fixation implants on maxillofacial skeleton girders. These axial implants are manufactured by machines with standard diameters and lengths defined for all implant brands. It is the same for basal plate implants. The sustainability of these devices, in contact with living media, seems to be related to the mechanical and surface characteristics of implanted parts. The development of periodontal diseases like peri-implantites, caused by a bacterial grip, leads to the removal of the implant due to the long term destruction of the oxide layer and the bacterial corrosion of titanium. In order to understand the sustainability of dental implants, an experimental study was conducted on the determination of elastic and surface properties (roughness parameters) of various materials and for different surface conditions. The results show that the knowledge of these characteristics alone is insufficient to understand the sustainability of implanted devices. A biological improvement of the surface condition is necessary to avoid the loss of osseointegration by bacterial attack.

References:
CharalampakasisG., Rabe P. Leonhardt A, Dahlen G, A follow-up study of prei-implantitis cases after treatment. J. Clin. Periodontol 38-9(2011) 864-871
Maloney WJ, Smith RL, Castro F, Schuman DJ, Fibroblat response to mettalic debris in vitro. Enzyme infuction cell proliferation and toxicity. J. Bone Joint Surg. Am 75-6(1993) 835-844

SESSION: SISAMThuPM1-R3 B: Bio is beautiful	Kobe International Symposium on Science of Innovative and Sustainable Alloys and Magnets (5th Intl. Symp. on Science of Intelligent and Sustainable Advanced Materials (SISAM))
Thu Oct, 24 2019 / Room: Dr. Christian Bernard
Session Chairs: Saso Sturm; Session Monitor: TBA

15:15: [SISAMThuPM108]
A Surface Mechanical Approach of the Sustainability of Implantable Medical Devices
Richard Kouitat Njiwa¹ ; ¹Institut Jean Lamour (UMR 7198 CNRS-Université de Lorraine), Nancy, France;
Paper Id: 186 [Abstract]

Many therapeutic fields use implantable medical devices. This usually involves replacing a whole organ or a defective part of an organ by a biocompatible substitute. Knee prostheses, hip prostheses, dental prostheses and breast prostheses are among the best-known implantable medical devices. These biomedical materials are intended to be in long-term contact with biological materials. Cells contained in these biological materials detect and react to their environment. This mechano-transduction process greatly influences the physiological processes involved in development, health and disease. The mechanical function of cells impacts, among other things, the processes of healing, differentiation of stem cells, and cancer metastases [1]-[4]. The impact of the contact forces developed between the implant and the biological tissue on changes in the behavior of the tissue has not yet received much attention from the scientific community. This is mainly because the mechanical constitutive equation of biological tissues is not available due to their complex microstructure. We believe that biological tissues can be considered as micromorphic media. It is actually the most achieved phenomenological top-down approach. The effectiveness of this modelling is investigated by considering the examples of an implant/bone system and a stent/artery system. The presented study is completely numerical and supported by clinical observations.

References:
[1] D. E. Discher, "Tissue Cells Feel and Respond to the Stiffness of Their Substrate", Science, vol. 310, no 5751, p. 1139-1143, nov. 2005.
[2] D. E. Jaalouk et J. Lammerding, "Mechanotransduction gone awry", Nature Reviews Molecular Cell Biology, vol. 10, no 1, p. 63-73, janv. 2009.
[3] A. Mammoto et al., "A mechanosensitive transcriptional mechanism that controls angiogenesis", Nature, vol. 457, no 7233, p. 1103-1108, févr. 2009.
[4] P. Friedl, Y. Hegerfeldt, et M. Tusch, "Collective cell migration in morphogenesis and cancer", The International Journal of Developmental Biology, vol. 48, no 5-6, p. 441-449, 2004.