ORALS

SESSION: OxidativeThuAM-R5	Intl. Symp. on Oxidative Stress for Sustainable Development of Human Beings
Thu Oct, 24 2019 / Room: Zeus (55/Mezz. F)
Session Chairs: Christian Amatore; HARUHIKO INUFUSA; Session Monitor: TBA

11:20: [OxidativeThuAM01]
The Effect of Ginseng on Human Antioxidant Capacity
Hiroshi Ichikawa¹ ; Yuta Noguchi² ; Maryam Shafei² ; Chiharu Myo² ; Keiko Kobayashi³ ; Yukiko Minamiyama⁴ ; Haruhiko .inufusa⁵ ; Toshikazu Yoshikawa⁶ ; ¹Doshisha University, Kyotanabe City, Japan; ²Major of Medical Life Systems, Graduate School of Life and Medical Sciences, Doshisha University, Kyotanabe City, Japan; ³Kyoto Prefectural University, Kyoto, Japan; ⁴Kyoto Prefectural University, KYoto, Japan; ⁵CEO, TIMA/Gifu University, Osaka, Japan; ⁶Louis Pasteur Center for Med. Res., Tohoku, Japan;
Paper Id: 219 [Abstract]

Ginseng has been reported about for its immunostimulation and its effects on various diseases such as obesity, diabetes and cancer. In this study, from the viewpoint of antioxidant and oxidative stress, the influence of ginseng on humans was examined. By using the MULTIple free-radical Scavenging (MULTIS method), we measured the scavenging activity of the reactive oxygen species: hydroxyl radical (・OH), superoxide radical (O₂^・-), alkyloxy radical (RO・), alkyl peroxy radical (ROO・), methyl radical (・CH₃), and singlet oxygen (¹O₂). We also evaluated the antioxidant capacity multifaceted. On the first day, subjects’ samples (plasma and saliva) were taken before ingesting ginseng tablets (n=5). After that, the samples were taken again, 4 hours after the administration of 18 tablets. They continued taking 18 tablets per day from the second day to the sixth day. On the seventh day, the samples were collected. The antioxidant capacity of the samples was examined using the MULTIS method. By ingestion of ginseng tablets, the ・OH scavenging activity of samples increased after 1 week. Also, plasma ・CH₃, and saliva O₂^・- scavenging activity increased. It was suggested that ginseng improved the antioxidant capacity of human.

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