2024 - Sustainable Industrial Processing Summit
SIPS 2024 Volume 14. Intl. Symp on Advanced Materials, Manufacturing, Magnesium and Aluminum
| Editors: | F. Kongoli, F. Marquis, N. Chikhradze, T. Prikhna, E. Suhir, Y. Yang |
| Publisher: | Flogen Star OUTREACH |
| Publication Year: | 2024 |
| Pages: | 258 pages |
| ISBN: | 978-1-998384-30-3 (CD) |
| ISSN: | 2291-1227 (Metals and Materials Processing in a Clean Environment Series) |
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MXene/nano-chitin/PVA MULTIFUNCTIONAL HYDROGEL WITH BIOMIMETIC ELECTRICAL STIMULATION AND NEAR-INFRARED EFFECT TO PROMOTE WOUND HEALING
Shuhao Jiao1; Xuejing Zheng1;1ZHENGZHOU UNIVERSITY, Zhengzhou, China;
Type of Paper: Regular
Id Paper: 112
Topic: 43
Abstract:
Safeguarding wounds against secondary infections and facilitating expedited wound healing are pivotal concerns in various domains, including everyday life, clinical practice, and other contexts. Compared to traditional healing therapy, electrical stimulation therapy (ES) effectively modulates cellular behavior, promotes cell proliferation and migration, and is extensively utilized in clinical treatment. In this study, MXene, nano-chitin (Ch), and polyvinyl alcohol (PVA) multifunctional hydrogels were investigated for their exceptional mechanical properties, antibacterial activity, and biocompatibility. Leveraging the self-healing property of PVA hydrogel, a novel ring splicing dressing was designed to guide the directional electric field from the wound edge towards the wound center, thereby enhancing the endogenous electric field within the wound. Experimental results using a rat skin defect model demonstrated that the hydrogel significantly accelerated the healing process with enhanced efficiency compared to conventional dressings. This study highlights a facile approach for the preparation of MXene/Ch/PVA hydrogels with enhanced wound healing capability, while introducing novel strategies for the development of electrotherapeutic dressings through its unique ring structure design.