2024 - Sustainable Industrial Processing Summit
SIPS2024 Volume 1. Abe Intl. Symp. / Oxidative Stress of Human Beings
| Editors: | F. Kongoli, H. Inufusa, T. Yoshikawa, C-A. Amatore, H-Y. Chen, W-H. Huang |
| Publisher: | Flogen Star OUTREACH |
| Publication Year: | 2024 |
| Pages: | ## pages |
| ISBN: | 978-1-998384-04-4 (CD) |
| ISSN: | 2291-1227 (Metals and Materials Processing in a Clean Environment Series) |
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THE DISCOVERY OF THE FUNDAMENTAL NEUROBIOLOGICAL MECHANISM BEHIND 4E-BP2 PROTEIN DEAMIDATION AND ITS IMPACT ON DEVELOPING EFFECTIVE TREATMENTS AGAINST NEURODEGENERATIVE DISEASES
Davis Joseph1;1MCGILL UNIVERSITY, Montreal, Canada;
Type of Paper: Regular
Id Paper: 465
Topic: 46
Abstract:
Memory impairment is caused by the absence of the 4E-BP2 protein in the brain. This protein undergoes deamidation spontaneously in the neurons. 4E-BP2 deamidation significantly alters protein synthesis in the neurons and affects the balance of protein production required for a healthy nervous system. Any imbalance in protein production in the nervous system causes neurodegenerative diseases. Discovering what causes 4E-BP2 deamidation will make it possible to control this balance of protein production and develop effective treatments against neurodegenerative diseases such as Alzheimer’s and Parkinson’s. The purpose of this work is to discover the neurobiological mechanism that causes the deamidation reaction in the 4E-BP2 protein by performing immunoblotting in the retinal ganglia, the optic nerve, the dorsal root ganglia, the sciatic nerve, and the whole brain, extracted via dissection from 2-month-old, Wild-type male mice. The results show that axons and their unique properties cause neuron-specific 4E-BP2 deamidation in the nervous system, confirming conclusively that axons are the critical factors behind the fundamental neurobiological mechanism of 4E-BP2 protein deamidation.