The current period is the era of Nanoscience (Nanomaterial and Nanotechnology), where revolutions in practically all subjects of Science and Technologies relax life that reflects an extensive investigation area which encompasses Nanodevices, their unique structures, and systems with innovative possessions and novel roles linked to the prearrangement of their atoms or molecules on the 1–100 nm scale. To understand the function and activity of NPs, it is essential to expose how NPs work in almost all fields of Science and Technology, such as engineering, materials and pharmaceutical sciences, physics, chemistry, biology, and computer science. The activity or action of NPs at the microsize level, including atoms, molecules, tubes or fiber based to inhabit the electronic system, move around in orbit; this orbit may be considered a surface for the electron where the electron interacts as energy to the surrounding molecules and determine the effectiveness of the Nanoparticle. The activity of NPs may be linked with the dual nature of the particle, where size (matter) and energy are adequate. The high activity of the small size of the NPs is based on energy, which in turn is related to the surface electron as NP showed an increased surface-to-volume ratio that must be intact with outer orbit. This report demonstrates the actions of NPs in the advancement of key ethics of Nanoscience and technology in the contemporary timeline period of findings and indicators related to every field of Science.