In Honor of Nobel Laureate Prof. M Stanley Whittingham
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Avram HershkoTechnion Institute of TechnologyRoles Of Protein Degradation In Health And Disease Summit Plenary Back to Plenary Lectures » |
Abstract:Cellular proteins are in a dynamic state of constant synthesis and degradation. Protein degradation is important for the elimination of abnormal or damaged proteins and for cessation of the action of regulatory proteins when they are no longer needed. Proteins in cells are marked for degradation by linkage to ubiquitin, a small protein present in all cells. The ubiquitin system is involved in basic cellular processes necessary for health, such as the control of cell division, regulation of inflammatory and immune responses and embryonic development. Abnormalities in ubiquitin-mediated protein degradation play roles in many types of cancer and in neurodegenerative diseases. This information is being used fo the development of novel treatments for some of these diseases. |
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