2023-Sustainable Industrial Processing Summit
SIPS2023 Volume 7. Ozawa Intl. Symp. / Oxidative Stress of Human Beings

Editors:F. Kongoli, T. Yoshikawa, H. Inufusa, C. A. Amatore, H-Y. Chen, W-H. Huang, H. Van Goor
Publisher:Flogen Star OUTREACH
Publication Year:2023
Pages:96 pages
ISBN:978-1-989820-84-1 (CD)
ISSN:2291-1227 (Metals and Materials Processing in a Clean Environment Series)
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    COMBINATION SUPPLEMENT, TWENDEE X IMPROVES LEARNING DYSFUNCTION IN LONG-TERM VITAMIN E-DEFICIENT MICE

    Koji Fukui1; Fuhua YANG2; Yoshiaki Harakawa2; Toshikazu Yoshikawa3; HARUHIKO INUFUSA2;
    1SHIBAURA INST. OF TECHNOLOGY, Saitama, Japan; 2GIFU UNIVERSITY, Gifu, Japan; 3LOUIS PASTEUR CENTER, Kyoto, Japan;
    Type of Paper: Regular
    Id Paper: 154
    Topic: 54

    Abstract:

    Vitamin E deficiency accelerates in vivo oxidation and is closely related to aging. Accumulation of oxidative products increases risk of developing serious disorders such as dementia and cardiovascular events [1]. Normally, our bodies maintain a balance between oxidation and reduction, but the redox balance gradually collapses as we age. To prevent oxidation, we should take supplements. The supplement market is growing year by year all over the world. One combination supplement is Twendee X, which contains 8 substances [2]. However, the detailed scientific evidence for Twendee X has not yet been elucidated. In this study, long-term vitamin E-deficient mice were fed Twendee X and measured cognitive and motor functions using the Morris water maze and rota-rod tests [3]. Vitamin E-deficient mice had significantly impaired cognitive and motor functions, learning rate was comparable to normal aged mice. Treatment with Twendee X significantly improved both dysfunctions. However, serum indices did not differ with or without Twendee X. These results indicate that Twendee X has a potential as a powerful antioxidant supplement through protection against in vitro oxidation.

    Keywords:

    Ageing; Anti-Oxidants; Brain Diseases; Neurodegenerative Diseases; Oxidative Stress; Reactive Oxygen Species (ROS); Tocopherol

    References:

    [1] Yoshida, N, Kato, Y, Takatsu, H, et al., Biomedicines 10 (2022) 28.
    [2] Tadokoro, K, Morihara, R, Ohta, Y, et al., J Alzheimer’s Dis, 71 (2019) 1063-1069.
    [3] Fukui, K, Onodera, K, Shinkai, T, et al., Ann NY Acad Sci, 928 (2001) 169-176.

    Cite this article as:

    Fukui K, YANG F, Harakawa Y, Yoshikawa T, INUFUSA H. (2023). COMBINATION SUPPLEMENT, TWENDEE X IMPROVES LEARNING DYSFUNCTION IN LONG-TERM VITAMIN E-DEFICIENT MICE. In F. Kongoli, T. Yoshikawa, H. Inufusa, C. A. Amatore, H-Y. Chen, W-H. Huang, H. Van Goor (Eds.), Sustainable Industrial Processing Summit Volume 7 Ozawa Intl. Symp. / Oxidative Stress of Human Beings (pp. 55-56). Montreal, Canada: FLOGEN Star Outreach