2023-Sustainable Industrial Processing Summit
SIPS2023 Volume 7. Ozawa Intl. Symp. / Oxidative Stress of Human Beings

Editors:F. Kongoli, T. Yoshikawa, H. Inufusa, C. A. Amatore, H-Y. Chen, W-H. Huang, H. Van Goor
Publisher:Flogen Star OUTREACH
Publication Year:2023
Pages:96 pages
ISBN:978-1-989820-84-1 (CD)
ISSN:2291-1227 (Metals and Materials Processing in a Clean Environment Series)
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    TWENDEE MT CONTROL IMPROVES COGNITIVE FUNCTION IN AGED MICE

    Koji Fukui1; Fuhua YANG2; Yugo Kato3; Shuya Yuzawa4; Ayuta Kishimoto4; Takuma Hara4; Yuki Kanome4; Yoshiaki Harakawa2; Toshikazu Yoshikawa5; HARUHIKO INUFUSA2;
    1SHIBAURA INST. OF TECHNOLOGY, Saitama, Japan; 2GIFU UNIVERSITY, Gifu, Japan; 3TOTTORI UNIVERSITY, Yonago, Japan; 4SHIBAURA INSTITUTE OF TECHNOLOGY, Saitama, Japan; 5LOUIS PASTEUR CENTER, Kyoto, Japan;
    Type of Paper: Regular
    Id Paper: 153
    Topic: 54

    Abstract:

    Aging is a universal degenerative disease. Aging is classified into physiological and pathological. The progression rate of pathological aging varies among individuals, and reactive oxygen species is deeply involved in pathological aging. One of the most serious phenomena during aging is dementia. To prevent age-related neurodegenerative disorders, treatment with antioxidants is effective. Twendee Mt Control which is a supplement contains 15 substances and anyone can buy it. However, the detailed scientific evidence is not enough. In the present study, we treated combination supplement to aged mice, and measured their cognitive and motor functions. 

    We purchased aged mice and treated them with Twendee Mt Control for one month. Cognitive and motor functions were measured by the Morris Water maze and rota-rod test [1]. Normal aged mice had significantly reduced learning ability. Treatment with Twendee Mt Control improved significantly. Twendee Mt Control significantly improved time-to-fall scores on the rota-rod test. Finally, treatment with Twendee Mt Control showed a high training effect in the treadmill test. These results indicated that treatment with Twendee Mt Control has a potential as a powerful antioxidant supplement through protection against age-related neuronal and motor dysfunctions.

     

     

    Keywords:

    Ageing; Anti-Oxidants; Brain Diseases; Neurodegenerative Diseases; Oxidative Stress; Reactive Oxygen Species (ROS)

    References:

    [1] [1] Fukui, K, Onodera, K, Shinkai, T, et al., Ann NY Acad Sci, 928 (2001) 169-176.

    Cite this article as:

    Fukui K, YANG F, Kato Y, Yuzawa S, Kishimoto A, Hara T, Kanome Y, Harakawa Y, Yoshikawa T, INUFUSA H. (2023). TWENDEE MT CONTROL IMPROVES COGNITIVE FUNCTION IN AGED MICE. In F. Kongoli, T. Yoshikawa, H. Inufusa, C. A. Amatore, H-Y. Chen, W-H. Huang, H. Van Goor (Eds.), Sustainable Industrial Processing Summit Volume 7 Ozawa Intl. Symp. / Oxidative Stress of Human Beings (pp. 61-62). Montreal, Canada: FLOGEN Star Outreach