2023-Sustainable Industrial Processing Summit
SIPS2023 Volume 7. Ozawa Intl. Symp. / Oxidative Stress of Human Beings

Editors:F. Kongoli, T. Yoshikawa, H. Inufusa, C. A. Amatore, H-Y. Chen, W-H. Huang, H. Van Goor
Publisher:Flogen Star OUTREACH
Publication Year:2023
Pages:96 pages
ISBN:978-1-989820-84-1 (CD)
ISSN:2291-1227 (Metals and Materials Processing in a Clean Environment Series)
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    APPLICATION OF AN ANTIOXIDANT COMBINATION PRODUCT IN THE TREATMENT OF SYSTEMIC SCLEROSIS

    Fuhua YANG1; Yoshiaki Harakawa1; Toshikazu Yoshikawa2; HARUHIKO INUFUSA1;
    1GIFU UNIVERSITY, Gifu, Japan; 2LOUIS PASTEUR CENTER, Kyoto, Japan;
    Type of Paper: Regular
    Id Paper: 107
    Topic: 54

    Abstract:

    Systemic sclerosis (SSc) is a disease of hardening of the skin and internal organs which is presumed to be caused by a complex combination of autoimmunity, fibrosis, and vascular lesions, yet the detailed mechanism is unknown. There is no established treatment, and women are at higher risk of developing the disease than men.
    The involvement of reactive oxygen species (ROS) in Raynaud's phenomenon and anti-PDGFR (Platelet-Derived Growth Factor Receptor)-stimulating autoantibodies in SSc has been suggested. In fact, dermal fibroblasts of SSc patients produce large amounts of ROS themselves, which induce collagen synthesis. Therefore, SSc is considered to be closely associated with elevated levels of oxidative stress.
    Twendee X (TwX, Oxicut®︎) is an antioxidant compound with mitochondrial protection properties that contains eight different ingredients, and studies have shown that TwX can potentially improve intestinal microbiota, chronic fatigue syndrome, sleep apnea, and more.
    We tested whether TwX has an ameliorative effect on SSc using a hypochlorous acid (HOCl)-induced SSc mouse model. Mouse SSc induced by oxidants such as HOCl is said to exhibit clinical and biological manifestations very similar to those observed in human SSc, including skin and visceral fibrosis, vascular damage, and autoimmunity.
    One month prior to the 6-week HOCl administration, mice were given drinking water (Control) or TwX-containing water ad libitum, and were dissected 2 days after the last HOCl administration to compare their skin lesions, immune status, and major protein expression with the Control group. The study showed that TwX had a favorable effect on clinical, immune, and physiological parameters in HOCl-induced SSc mice.
    These results suggest that TwX may aid in the treatment and prevention of SSc.

    Keywords:

    Anti-Oxidants; Antioxidant Therapeutic Options; Auto-immune Diseases; Oxidative Stress; Free Radicals; Reactive Oxygen Species (ROS);

    References:

    1) Batteux F, Kavian N, Servettaz A. New insights on chemically induced animal models of systemic sclerosis. Current opinion in rheumatology. 2011
    2) Ogawa F, Shimizu K, Takehara K, et al. Serum levels of 8-isoprostane, a marker of oxidative stress, are elevated in patients with systemic sclerosis. Rheumatology (Oxford). 2006;45(7):815-8.
    3) Sambo P, Baroni SS, Orlandini G, et al. Oxidative stress in scleroderma: maintenance of scleroderma fibroblast phenotype by the constitutive up-regulation of reactive oxygen species generation through the NADPH oxidase complex pathway. Arthritis and rheumatism. 2001 Nov;44(11):2653-64.
    4) Novel compositions and uses thereof WO 2008071790 A3.
    5) Antioxidant composition and its use in diabetes EP 1932542 A1.

    Cite this article as:

    YANG F, Harakawa Y, Yoshikawa T, INUFUSA H. (2023). APPLICATION OF AN ANTIOXIDANT COMBINATION PRODUCT IN THE TREATMENT OF SYSTEMIC SCLEROSIS. In F. Kongoli, T. Yoshikawa, H. Inufusa, C. A. Amatore, H-Y. Chen, W-H. Huang, H. Van Goor (Eds.), Sustainable Industrial Processing Summit Volume 7 Ozawa Intl. Symp. / Oxidative Stress of Human Beings (pp. 59-60). Montreal, Canada: FLOGEN Star Outreach