2023-Sustainable Industrial Processing Summit
SIPS2023 Volume 11. Intl. Symp on Technological Innovations in Medicine
| Editors: | F. Kongoli, F. Murad, T. Yoshikawa, J.R. Ribas, D. Joseph, N. Tran, S. Hirano |
| Publisher: | Flogen Star OUTREACH |
| Publication Year: | 2023 |
| Pages: | 126 pages |
| ISBN: | 978-1-989820-92-6 (CD) |
| ISSN: | 2291-1227 (Metals and Materials Processing in a Clean Environment Series) |
CD shopping page
FOCUSED DELIVERY OF CHENOTHERAPY TO AUGMENT SURGICAL MANAGEMENT OF BRAIN TUMORS
Brandon Lucke-Wold 1;1UNIVERSITY OF FLORIDA, ., United States;
Type of Paper: Regular
Id Paper: 525
Topic: 65
Abstract:
Chemotherapy as an adjuvant therapy that has largely failed to significantly improve outcomes for aggressive brain tumors; some reasons include a weak blood brain barrier penetration and tumor heterogeneity. Recently, there has been interest in designing effective ways to deliver chemotherapy to the tumor. In this review, we discuss the mechanisms of focused chemotherapies that are currently under investigation. Nanoparticle delivery demonstrates both a superior permeability and retention. However, thus far, it has not demonstrated a therapeutic efficacy for brain tumors. Convection-enhanced delivery is an invasive, yet versatile method, which appears to have the greatest potential. Other vehicles, such as angiopep-2 decorated gold nanoparticles, polyamidoamine dendrimers, and lipid nanostructures have demonstrated efficacy through sustained release of focused chemotherapy and have either improved cell death or survival in humans or animal models. Finally, focused ultrasound is a safe and effective way to disrupt the blood brain barrier and augment other delivery methods. Clinical trials are currently underway to study the safety and efficacy of these methods in combination with standard of care.