2023-Sustainable Industrial Processing Summit
SIPS2023 Volume 1. Assis Intl. Symp/ Advanced Iron & Steel Making
| Editors: | F. Kongoli, T. Usui, R.A. Vilela, J. A. de Castro, W. F. Santos, J. Poveromo, GS. Mahobia, B. Deo |
| Publisher: | Flogen Star OUTREACH |
| Publication Year: | 2023 |
| Pages: | 441 pages |
| ISBN: | 978-1-989820-72-8 (CD) |
| ISSN: | 2291-1227 (Metals and Materials Processing in a Clean Environment Series) |
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ROLES OF PROTEIN DEGRADATION IN HEALTH AND DISEASE
Avram Hershko1;1TECHNION INSTITUTE OF TECHNOLOGY, Mont-Royal, Israel;
Type of Paper: General Plenary
Id Paper: 511
Topic: 46
Abstract:
Cellular proteins are in a dynamic state of constant synthesis and degradation. Protein degradation is important for the elimination of abnormal or damaged proteins and for cessation of the action of regulatory proteins when they are no longer needed. Proteins in cells are marked for degradation by linkage to ubiquitin, a small protein present in all cells. The ubiquitin system is involved in basic cellular processes necessary for health, such as the control of cell division, regulation of inflammatory and immune responses and embryonic development. Abnormalities in ubiquitin-mediated protein degradation play roles in many types of cancer and in neurodegenerative diseases. This information is being used fo the development of novel treatments for some of these diseases.