In Honor of Nobel Laureate Prof. M Stanley Whittingham
| A SUSTAINABLE CARBON-BASED PLATFORM FOR INTERVENTION IN NEURODEGENERATION Mahesh Narayan1; 1THE UNIVERSITY OF TEXAS AT EL PASO, El Paso, United States; PAPER: 4/Oxidative/Regular (Oral) OS SCHEDULED: 12:20/Thu. 30 Nov. 2023/Dreams 1 ABSTRACT: Carbon quantum dots (CQDs), depending on their surface functionalization, have found utility across a number of biological applications [1-4]. Here, we demonstrate that individual CQDs can serve multifunctional roles, which is a key requisite for the development of drugs for neurodegenerative disorders such as Parkinson’s disease (PD) [5]. Na-citrate-, phenylboronic acid-, and 4-aminophenylboronic acid-derived CQDs were evaluated for their ability to intervene in amyloid-forming trajectories and restore intracellular homeostasis under oxidative stress. While all three CQDs were able to prevent the soluble-monomer to mature-fibril conversion of hen-egg white lysozyme, Na-citrate- and 4-aminophenylboronic acid-derived CQDs in particular were also able to scavenge reactive oxygen species when exposed to a broad spectrum of free radical generators. Furthermore, Na-citrate and 4-aminophenylboronic acid CQDs preincubated in a neuroblastoma-derived SHSY-5Y cell line were able to rescue it from rotenone (neurotoxicant)-induced cell death while demonstrating no difference in cytotoxicity up to 120 μg/mL (compared to untreated controls). The CQDs were also able to restitute cells from rotenone-elicited apoptosis and oxidative stress. Together, these results suggest that CQDs can serve as a one-pot solution for multifactorial diseases such as PD by serving as a neuroprotectant. Importantly, the use of CQDs as multifactorial interventional agents represents a sustainable mechanism by which to advance biomedicine. References: [1] Savelieff, M. G.; Nam, G.; Kang, J.; Lee, H. J.; Lee, M.; Lim, M. H. Development of multifunctional molecules as potential therapeutic candidates for Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis in the last decade. Chem. Rev. 2019, 119 (2), 1221– 1322, DOI: 10.1021/acs.chemrev.8b00138 [2] De, B.; Karak, N. A green and facile approach for the synthesis of water soluble fluorescent carbon dots from banana juice. RSC Adv. 2013, 3 (22), 8286– 8290, DOI: 10.1039/c3ra00088e [3] Sachdev, A.; Gopinath, P. Green synthesis of multifunctional carbon dots from coriander leaves and their potential application as antioxidants, sensors and bioimaging agents. Analyst 2015, 140 (12), 4260– 4269, DOI: 10.1039/C5AN00454C [4] Molaei, M. Carbon quantum dots and their biomedical and therapeutic applications: a review. RSC Adv. 2019, 9 (12), 6460– 6481, DOI: 10.1039/C8RA08088G |
