Vitamin E deficiency accelerates in vivo oxidation and is closely related to aging. Accumulation of oxidative products increases risk of developing serious disorders such as dementia and cardiovascular events [1]. Normally, our bodies maintain a balance between oxidation and reduction, but the redox balance gradually collapses as we age. To prevent oxidation, we should take supplements. The supplement market is growing year by year all over the world. One combination supplement is Twendee X, which contains 8 substances [2]. However, the detailed scientific evidence for Twendee X has not yet been elucidated. In this study, long-term vitamin E-deficient mice were fed Twendee X and measured cognitive and motor functions using the Morris water maze and rota-rod tests [3]. Vitamin E-deficient mice had significantly impaired cognitive and motor functions, learning rate was comparable to normal aged mice. Treatment with Twendee X significantly improved both dysfunctions. However, serum indices did not differ with or without Twendee X. These results indicate that Twendee X has a potential as a powerful antioxidant supplement through protection against in vitro oxidation.