| Antioxidant treatment for infertility Haruhiko Inufusa1; Fuhua Yang2; Naomi Okada3; Toshikazu Yoshikawa4; 1TIMA, Gifu, Japan; 2DIVISION OF ANTI-OXIDANT RESEARCH, GIFU UNIVERSITY, Gifu, Japan; 3GIFU UNIVERSITY, Gifu, Japan; 4LOUIS PASTEUR CENTER, Kyoto, Japan; PAPER: 122/Oxidative/Plenary (Oral) SCHEDULED: 14:00/Mon. 28 Nov. 2022/Ballroom B ABSTRACT: The decline in fertility is a major problem in many countries, especially in Japan, where the total fertility rate in 2018 is 1.42. Half of infertility couples have male causes, and the other half have female causes. Oxidative stress can be a major cause of infertility. There are many reports that the number of spermatozoa is decreased by mobile phone that emits electromagnetic waves that cause oxidative stress in the pocket near the testicle, resulting in a decrease in motility. The decline in pregnancy rates with age in women is partly due to the firmness of the egg membrane due to oxidative stress. Administration of an antioxidant composition would increase the pregnancy rate was examined. The monitor questionnaire was conducted by EYEZ,INC., which is a third-party institution, and the permission for secondary use of the results listed on the company's website (public data) was obtained. Twendee Mtcontrol (TwM) was used as antioxidant composition, which contains L-glutamine, ascorbic acid (VC), L-cystine, coenzyme Q10, succinic acid, fumaric acid, vitamin B2, niacin, Pantothenic acid, thiamine (VB1), pyridoxamine (VB6), folic acid, biotin, vitamin B12, lactoferrin. Twenty-eight couples who had been infertile for more than 2 years and wanted to raise their children joined the monitor questionnaire. For 1 year, both couples took TwM and their pregnancy was monitored. As a result, 9 pairs became pregnant, and the rate was 32% (9/28). Pregnancy rate is about 16% for a couple of more than two years of infertility when they receive infertility treatment at hospital. TwM showed almost 3 times higher pregnancy rate than infertility treatment at hospital. The possibility of antioxidant treatment for infertility was suggested. References: 1.Novel compositions and uses thereof WO 2008071790 A3 2.Antioxidant composition and its use in diabetes EP 1932542 A1 3.Pretreatment Twendee X® reduced acute ischemic brain damage. Kusaki M, Inufusa H, Abe K, JSCVD 2017; 26: 1191-1196 4.Clinical and Pathological Benefit of Twendee X in Alzheimer's Disease Transgenic Mice with Chronic Cerebral Hypoperfusion. XiaLiu, Abe K https://doi.org/10.1016/j.jstrokecerebrovasdis.2019.03.029 |
