Jun-Jie Zhu

Abstract:

Cancer is a conundrum in modern medicine and has become a serious threat to human health and life [1], thus the the early diagnosis and precise therapy are crucial to improve the cancer cure rates [2]. Taking advantage of the DNA nanotechnology, an RNA aptamer-based near-infrared gated nanodevice for low-background imaging of mRNA in living cells have been first developed based on the fluorescence enhancement property of RNA aptamer and the catalytic hairpin assembly reaction-mediated signal amplification strategy. Subsequently, DNA nanocarrier with excellent biological stability, strong enzymatic resistance and collaborative drugs delivery is constructed by functionalized circular DNA, which can effectively combat the multidrug-resistant human leukemia. Moreover, a multifunctional DNA-Au nanomachine integrating both diagnostic and therapeutic agents is proposed, which can be triggered by the endogenous mRNA, leading to the activation of multi-mode synergistic therapy and in situ imaging. These researches conducive to the accurate diagnosis and image-guided precise treatment of cancers, which may provide a new route for the construction of intelligent responsive theranostic nanoplatform.