2022-Sustainable Industrial Processing Summit
SIPS2022 Volume 15 Yoshikawa Intl. Symp Oxidative Stress of Human Beings
| Editors: | F. Kongoli, H. Inufusa, C. Amatore, H. Chen, W. Huang, H. Goor. |
| Publisher: | Flogen Star OUTREACH |
| Publication Year: | 2022 |
| Pages: | 152 pages |
| ISBN: | 978-1-989820-62-9(CD) |
| ISSN: | 2291-1227 (Metals and Materials Processing in a Clean Environment Series) |
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DNA Nano Self-assemblies for the Application in Cancer Diagnosis and Therapy
Jun-Jie Zhu1;1NANJING UNIVERSITY, NANJING, CHINA, Nanjing, China;
Type of Paper: Keynote
Id Paper: 535
Topic: 54
Abstract:
Cancer is a conundrum in modern medicine and has become a serious threat to human health and life [1], thus the the early diagnosis and precise therapy are crucial to improve the cancer cure rates [2]. Taking advantage of the DNA nanotechnology, an RNA aptamer-based near-infrared gated nanodevice for low-background imaging of mRNA in living cells have been first developed based on the fluorescence enhancement property of RNA aptamer and the catalytic hairpin assembly reaction-mediated signal amplification strategy. Subsequently, DNA nanocarrier with excellent biological stability, strong enzymatic resistance and collaborative drugs delivery is constructed by functionalized circular DNA, which can effectively combat the multidrug-resistant human leukemia. Moreover, a multifunctional DNA-Au nanomachine integrating both diagnostic and therapeutic agents is proposed, which can be triggered by the endogenous mRNA, leading to the activation of multi-mode synergistic therapy and in situ imaging. These researches conducive to the accurate diagnosis and image-guided precise treatment of cancers, which may provide a new route for the construction of intelligent responsive theranostic nanoplatform.
References:
[1] H. Dong, J. Lei, L. Ding, Y. Wen, H. Ju, X. Zhang, Chem. Rev. 113 (2013) 6207.[2] X. Zhang, Z. Xi, J. O. Machuki, Y. Yang, L. Zhang, J. Tian, K. Guo, Y. Yu, F. Gao, ACS Nano 13 (2019), 5306.