2022-Sustainable Industrial Processing Summit
SIPS2022 Volume 15 Yoshikawa Intl. Symp Oxidative Stress of Human Beings

Editors:F. Kongoli, H. Inufusa, C. Amatore, H. Chen, W. Huang, H. Goor.
Publisher:Flogen Star OUTREACH
Publication Year:2022
Pages:152 pages
ISBN:978-1-989820-62-9(CD)
ISSN:2291-1227 (Metals and Materials Processing in a Clean Environment Series)
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    A multi-antioxidant complex, Twendee X improves spatial learning ability in vitamin E-deficient mice

    Koji Fukui1; Fuhua Yang2; Yugo Kato1; Yoshiaki Harakawa3; Toshikazu Yoshikawa4; Haruhiko Inufusa5;
    1SHIBAURA INSTITUTE OF TECHNOLOGY, Saitama, Japan; 2DIVISION OF ANAEROBE RESEARCH, LIFU SCIENCE RESEARCH CENTER, GIFU UNIVERSITY, Gifu-city, Japan; 3DIVISION OF ANTI-OXIDANT RESEARCH, GIFU UNIVERSITY, Gifu, Japan; 4LOUIS PASTEUR CENTER, Kyoto, Japan; 5TIMA, Gifu, Japan;
    Type of Paper: Regular
    Id Paper: 440
    Topic: 54

    Abstract:

    Chronic vitamin E deficiency accelerates in vivo oxidation, which is closely related to aging. There is a significant increase in lipid hydroperoxides in the normal aged mouse brain, especially in the hippocampus compared with young controls. Accumulation of oxidative products induces risk of developing age-related disorders [1]. Normally, our bodies maintain a balance of oxidation and reduction, but the balance gradually collapses as we age. To prevent oxidation, we should always consume fresh fruits, vegetables and supplements. The supplement market is growing year by year. One antioxidant mixed supplement is Twendee X, which contains 8 substances [2]. However, the detailed beneficial effects of Twendee X have not yet been elucidated. In this study, vitamin E-deficient mice were given Twendee X and their cognitive function was measured [3]. Vitamin E-deficient mice had significantly reduced learning ability, the learning rate was comparable to normal aged mouse. Treatment with Twendee X significantly improved spatial ability, despite significantly slower swimming speeds than the untreated group. These results demonstrate that Twendee X has a potential as a powerful antioxidant supplement through protection of in vitro oxidation.

    Keywords:

    Anti-Oxidants; Oxidative Stress; Tocopherol; Reactive Oxygen Species (ROS); Antioxidant, Cognition, Vitamin E-deficiency

    References:

    [1] Yoshida, N, Kato, Y, Takatsu, H, et al., Biomedicines 10 (2022) 28.
    [2] Tadokoro, K, Morihara, R, Ohta, Y, et al., J Alzheimer’s Dis, 71 (2019) 1063-1069.
    [3] Fukui, K, Onodera, K, Shinkai, T, et al., Ann NY Acad Sci, 928 (2001) 169-176.

    Cite this article as:

    Fukui K, Yang F, Kato Y, Harakawa Y, Yoshikawa T, Inufusa H. (2022). A multi-antioxidant complex, Twendee X improves spatial learning ability in vitamin E-deficient mice. In F. Kongoli, H. Inufusa, C. Amatore, H. Chen, W. Huang, H. Goor. (Eds.), Sustainable Industrial Processing Summit SIPS2022 Volume 15 Yoshikawa Intl. Symp Oxidative Stress of Human Beings (pp. 147-148). Montreal, Canada: FLOGEN Star Outreach