2022-Sustainable Industrial Processing Summit
SIPS2022 Volume 15 Yoshikawa Intl. Symp Oxidative Stress of Human Beings

Editors:F. Kongoli, H. Inufusa, C. Amatore, H. Chen, W. Huang, H. Goor.
Publisher:Flogen Star OUTREACH
Publication Year:2022
Pages:152 pages
ISBN:978-1-989820-62-9(CD)
ISSN:2291-1227 (Metals and Materials Processing in a Clean Environment Series)
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    The effect of anti-oxidant Twendee X on swallowing function in an animal model of dysphagia in guinea pigs

    Yoichiro Sugiyama1; Keiko Hashimoto2; Shigeru Hirano3; Haruhiko Inufusa4; Toshikazu Yoshikawa5;
    1DEPARTMENT OF OTOLARYNOGOLGY-HEAD AND NECK SURGERY, KYOTO PREFECTURAL UNIVERSITY OF MEDICINE, Kyoto, Japan; 2DEPARTMENT OF OTOLARYNGOLOGY-HEAD AND NECK SURGERY, KYOTO PREFECTURAL UNIVERSITY OF MEDICINE, Kyoto, Japan; 3KYOTO PREFECTURAL UNIVERSITY OF MEDICINE, Kyoto, Japan; 4TIMA, Gifu, Japan; 5LOUIS PASTEUR MEDICAL RESEARCH CENTER, Kyoto, Japan;
    Type of Paper: Regular
    Id Paper: 433
    Topic: 54

    Abstract:

    Dysphagia is one of the significant concerns in the aging society. In particular, the elderly with swallowing impairment caused by either central or peripheral nervous systems has difficulty in oral intake, possibly resulting in fatal pneumonia. As such, the development of a therapeutic approach that decreases in the risk of aspiration in dysphagic patients remains a pressing issue for medical doctors. The purpose of our study was to establish the animal model of dysphagia and test the hypothesis that decreased pharyngeal constriction caused by the denervation of the vagal efferent nerves can be improved by the application of the anti-oxidant agent. Thus, we developed the animal model in guinea pigs in which the pharyngeal branch of the vagus nerve was cut and initially evaluated swallowing function using videofluoroscopy. We then tested the effect of oral application of the anti-oxidant agent Twendee X on swallowing function in the dysphagia model animals. Insufficient pharyngeal constriction and pharyngeal residue were found in the denervated animals. The swallowing dysfunction was less pronounced in dysphagic animals with the administration of Twendee X. In conclusion, Twendee X could have a possible role in the improvement of swallowing function in dysphagic patients with decreased swallowing muscle strength caused by neuromuscular atrophy.

    Keywords:

    Anti-Oxidants; Antioxidant Therapeutic Options; Oxidative Stress;

    Cite this article as:

    Sugiyama Y, Hashimoto K, Hirano S, Inufusa H, Yoshikawa T. (2022). The effect of anti-oxidant Twendee X on swallowing function in an animal model of dysphagia in guinea pigs. In F. Kongoli, H. Inufusa, C. Amatore, H. Chen, W. Huang, H. Goor. (Eds.), Sustainable Industrial Processing Summit SIPS2022 Volume 15 Yoshikawa Intl. Symp Oxidative Stress of Human Beings (pp. 131-132). Montreal, Canada: FLOGEN Star Outreach