2022-Sustainable Industrial Processing Summit
SIPS2022 Volume 15 Yoshikawa Intl. Symp Oxidative Stress of Human Beings
| Editors: | F. Kongoli, H. Inufusa, C. Amatore, H. Chen, W. Huang, H. Goor. |
| Publisher: | Flogen Star OUTREACH |
| Publication Year: | 2022 |
| Pages: | 152 pages |
| ISBN: | 978-1-989820-62-9(CD) |
| ISSN: | 2291-1227 (Metals and Materials Processing in a Clean Environment Series) |
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Real-Time Diagnosis of Reactive Oxygen Species (ROS) in Fresh Sputum by Electrochemical Tracing; Correlation Between COVID-19 and Viral-Induced ROS in Lung/Respiratory Epithelium
Mohammad Abdolahad1;1NANO ELECTRONIC CENTER OF EXCELLENCE, NANO BIO ELECTRONIC DEVICES LAB, SCHOOL OF ELECTRICAL AND COMPUTER ENGINEERING, COLLEGE OF ENGINEERING, UNIVERSITY OF TEHRAN, P.O. BOX: 14395/515, TEHRAN, IRAN, Tehran, Iran;
Type of Paper: Regular
Id Paper: 224
Topic: 54
Abstract:
COVID-19 is the shocking viral pandemics of this year which affected the health, economy, communications, and all aspects of social activities all over the world. Early diagnosis of this viral disease is very important since it can prevent lots of mortalities and care consumption.
The functional similarities between COVID-19 and COVID-2 in inducing acute respiratory syndrome lightened our mind to find a diagnostic mechanism based on early traces of mitochondrial reactive oxygen species (ROS) overproduction as lung cells’ dysfunctions induced by the virus. We designed a simple electrochemical sensor to selectively detect the intensity of ROS in the sputum sample (with a volume of less than 500µl). Comparing the results of the sensor with clinical diagnostics of more than 140 normal and involved cases resulted in a response calibration with accuracy and sensitivity both 97%. Testing the sensor in more than 4 hospitals shed promising lights in ROS based real-time tracing of COVID-19 from the sputum sample.