| ANTI-OXIDANT TWENDEE X FOR MAINTENANCE OF VOCAL AND SWALLOWING FUNCTION Shigeru Hirano1; Yoichiro Sugiyama2; Haruhiko Inufusa3; Toshikazu Yoshikawa4; 1KYOTO PREFECTURAL UNIVERSITY OF MEDICINE, Kyoto, Japan; 2DEPARTMENT OF OTOLARYNOGOLGY-HEAD AND NECK SURGERY, KYOTO PREFECTURAL UNIVERSITY OF MEDICINE, Kyoto, Japan; 3TIMA, Gifu, Japan; 4LOUIS PASTEUR CENTER, Kyoto, Japan; PAPER: 94/Oxidative/Regular (Oral) SCHEDULED: 15:15/Tue. 29 Nov. 2022/Ballroom B ABSTRACT: Voice and swallowing function are critical functions for human life which is supported by intriguing motion of pharynx and larynx. Swallowing function is complicated consisting of the motion of tongue, soft palate, pharyngeal muscles, laryngeal elevation, and the vocal folds. Reactive oxygen species (ROS) affects the whole organs and their functions, which deteriorate vocal and swallowing function with age or diseases. Dysphagia causes sarcopenia, frail, and aspiration pneumonia which occasionally causes death. It is important to maintain swallowing function as well as vocal function to keep the body in healthy status. Twendee X, the strongest anti-oxidant, can maintain the function of the pharynx and larynx by reducing ROS. Our previous data indicated that reduction of ROS leads to maintenance of the vocal folds against aging or injury. We have also confirmed that Twendee X can maintain the vocal function of professional singers. To date, we have established a dysphagia model of guinea pig by resecting nerve branches to the thyropharyngeal muscle. This model represents motor-related dysphagia which is often observed in elderly or patients with neuromuscular diseases. In this model, the animals became unable to eat immediately after the surgery, and lost weight for about 1 week, but they recovered by compensation. When the animals were fed with Twendee x, the immediate reduction of food intake was prevented possibly because of maintenance of the muscles. Twendee X is thought to be effective for maintenance of voice and swallowing function. |
