| Usefulness of Antioxidant Combination Products for Chronic Fatigue Syndrome Fuhua Yang1; Yoshiaki Harakawa1; Toshikazu Yoshikawa2; Haruhiko Inufusa3; 1DIVISION OF ANTI-OXIDANT RESEARCH, GIFU UNIVERSITY, Gifu, Japan; 2LOUIS PASTEUR CENTER, Kyoto, Japan; 3TIMA, Gifu, Japan; PAPER: 427/Oxidative/Regular (Oral) SCHEDULED: 15:55/Wed. 30 Nov. 2022/Ballroom B ABSTRACT: In Chronic Fatigue syndrome (CFS), a complex combination of factors such as infections and excessive stress in daily life causes abnormalities in the immune system, endocrine system, brain, and neurological functions. The pathogenesis of the syndrome is not yet clear, and no treatment has been established. Recently, it has been reported that CFS-like symptoms are also observed in COVID-19 sequelae and SARS-CoV-2 vaccine sequelae, and there is an urgent need to clarify the pathogenesis mechanism and establish prevention and treatment methods. Abnormal energy metabolism due to mitochondrial dysfunction and inflammation in the brain have been reported as one of the causes of CFS. Since oxidative stress is highly related to both of these factors, it was thought that suppressing oxidative stress may lead to improvement of various symptoms of CFS. Therefore, we analyzed the symptom changes before and after the use of an antioxidant combination supplement, Twendee Mtcontrol (TwM), taken by people who had been diagnosed with chronic fatigue syndrome. 2 months of TwM intake resulted not only in an anti-fatigue effect, but also in improvement of pains and QOL, compared to before intake. Although the effects of various antioxidants have been reported for CFS, most of them are mainly for fatigue, and there are no reports showing significant effects on various symptoms. This may be due to differences in the combination of antioxidants and their antioxidant capacity. The results of this study may be useful for future treatment and prevention of CFS. References: 1). Feng T, Yamashita T, Abe K, et al. In Vitro Free Radical Scavenging Activities of Dietary Supplements by Electron Spin Resonance. Brain Supplements. 2020; 2: 1-12. 2). You F, Tanaka S, Inufusa H, et al. Effects of Antioxidant composition Twendee X on side effects of SARS -COV-2 mRNA vaccine. Brain Supplement. 2022; 4: 1-6. 3). You F, Tanaka S, Inufusa H, et al. Antioxidant composition Twendee X may improve long COVID symptoms. Brain Supplement. 2022; 4: 7-12. |
