| Oxidative stress and hearing Shigeru Hirano1; 1KYOTO PREFECTURAL UNIVERSITY OF MEDICINE, Kyoto, Japan; PAPER: 421/Oxidative/Regular (Oral) SCHEDULED: 14:25/Wed. 30 Nov. 2022/Ballroom B ABSTRACT: Hearing loss can occur by aging, ototoxicity of drugs, noise exposure, etc. It deteriorates the quality of life. Severe hearing loss causes isolation in human life. Tinnitus is an accompanying symptom with hearing loss, and is kind of torture for some people. Prevention of hearing loss is essential to keep the comfortable human life. Oxidative stress has been revealed to cause hearing loss caused by aging, noise exposure, and ototoxic drugs such as aminoglycoside and cisplatin (CDDP). We have revealed that reactive oxygen species (ROS) is produced in the vessels and hair cells of the inner ear. The hair cells are critical to maintain the hearing ability, and ROS causes severe and refractory damage to the hair cells. We have also revealed that Nox-3 derived ROS in the cochlea induces sensorineural hearing loss. Nox-3 is the key molecule for production of ROS. Nox knock-out mice showed maintenance of hearing ability under noise exposure or ototoxic agency. Anti-oxidative supplement should be useful for maintaining hearing. |
