| Twendee X improves cognitive function in vitamin E-deficient mice Koji Fukui1; Fuhua Yang2; Yugo Kato1; Yoshiaki Harakawa2; Toshikazu Yoshikawa3; Haruhiko Inufusa4; 1SHIBAURA INSTITUTE OF TECHNOLOGY, Saitama, Japan; 2DIVISION OF ANTI-OXIDANT RESEARCH, GIFU UNIVERSITY, Gifu, Japan; 3LOUIS PASTEUR MEDICAL RESEARCH CENTER, Kyoto, Japan; 4TIMA, Gifu, Japan; PAPER: 419/Oxidative/Plenary (Oral) SCHEDULED: 14:00/Wed. 30 Nov. 2022/Ballroom B ABSTRACT: Reactive oxygen species may attack several living organs and gradually accumulate oxidative products such as lipid hydroperoxides. Recently, several kinds of evidence have been demonstrated that accumulation of oxidative products induces onset and progression of several severe diseases such as inflammations, cardiovascular events and more [1]. One severe disease is dementia, and it also deeply relates to senescence. To prevent age-related neurodegenerative disorders, treatment with antioxidant is effective. Twendee X, a mixed antioxidant supplement contains 8 substances [2] and anyone can buy it. However, the detailed scientific evidence is not enough. In this study, we fed Twendee X to vitamin E-deficient mice and check cognitive function.<br />We created vitamin E-deficient mice and Twendee X treated for one month. Cognitive function was measured by the Morris Water maze task [3].<br />Vitamin E deficient mice were significantly decrease learning ability. Treatment with Twendee X was significantly improved it. Brain neurotrophic factors in Twendee X-treated mouse were significantly increase compared to the untreated groups.<br />Twendee X has a potential as a powerful antioxidant supplement through protection against neuronal dysfunction. References: [1] Yoshida, N, Kato, Y, Takatsu, H, et al., Biomedicines 10 (2022) 28.<br />[2] Tadokoro, K, Morihara, R, Ohta, Y, et al., J Alzheimer’s Dis, 71 (2019) 1063-1069.<br />[3] Fukui, K, Onodera, K, Shinkai, T, et al., Ann NY Acad Sci, 928 (2001) 169-176. |
