| Oxidative stress is major cause of allergic reaction in COVID-19 infection Haruhiko Inufusa1; Fuhua Yang2; Naomi Okada3; Toshikazu Yoshikawa4; 1TIMA, Gifu, Japan; 2DIVISION OF ANTI-OXIDANT RESEARCH, GIFU UNIVERSITY, Gifu, Japan; 3GIFU UNIVERSITY, Gifu, Japan; 4LOUIS PASTEUR CENTER, Kyoto, Japan; PAPER: 123/Oxidative/Keynote (Oral) SCHEDULED: 12:45/Mon. 28 Nov. 2022/Ballroom B ABSTRACT: Oxidative stress and immune activity are closely related with disease or symptoms. Allergic reaction depending on imbalance of immune system which is easy to be damaged by oxidative stress. COVID-19 pneumonia starts at the lower and back side of lung, and CT scan shows typical interstitial pneumonia. Interstitial pneumonia is kind of allergic reaction, thus pneumonia start high blood flow area of lung and very rapidly spread to the whole lung. It is well known that interstitial pneumonia shows extremely high oxidative stress, damages lung tissue, and some patients show irreversible damage of the lung. High risks of COVID-19 infection are high age with underlying disease, especially diabetes mellitus, obesity, heart disease, hypertension, after stroke, cancer, neurogenic disorder, dementia and so on. All these risk factors show extremely high oxidative stress. Oxidative stress damages vascular endothelium and inflammation of vascular wall produces thrombosis, which are reasons of Kawasaki disease like vasculitis and cerebral infraction. Oxidative stress plays a major role in these symptoms. References: 1. Novel compositions and uses thereof WO 2008071790 A3 2. Antioxidant composition and its use in diabetes EP 1932542 A1 |
