| Oxidative Stress: Does Continuous Oxidative Stress Reduction Prevent and Ameliorate Diseases through Species Diversity of Intestinal Bacteria? Fuhua (fukka) Yang (you)1; Kaori Tanaka2; Haruhiko Inufusa3; 1GIFU UNIVERSITY DIVISION OF ANAEROBE RESEARCH, Gifu, Japan; 21) DIVISION OF ANAEROBE RESEARCH, LIFE SCIENCE RESEARCH CENTER, GIFU UNIVERSITY, Gifu, Japan; 3TIMA JAPAN CORPORATION, Gifu, Japan; PAPER: 226/Oxidative/Regular (Oral) SCHEDULED: 14:50/Thu. 24 Oct. 2019/Zeus (55/Mezz. F) ABSTRACT: Intestines are said to be involved in 60% of human immunity. More than 100 species, or 100 trillions of bacteria (intestinal bacteria) inhabit in the intestines and those bacteria can be divided into bad bacteria that trigger diseases, good bacteria that are considered to benefit health, and opportunistic bacteria. Regarding 20% of good, 10% of bad, and 70% of opportunistic bacteria as an ideal balance of gut bacteria, this balance can be disturbed by diarrhea, constipation and various diseases. In other words, oxidative stress can reduce diversity of gut bacteria. In that case, how does reducing oxidative stress alter gut microflora, and how does reducing oxidative stress affect daily defecation? Although administering antiseptic agent OPP to rats for 2 weeks increased their blood oxidative stress by 5%, there were no significant changes of bacterial gut diversity. Rats, however, were given a strong antioxidant composition, Twendee X(TWX), from 1 week before OPP decreased their oxidative stress by 13.3% against control, and increased bacterial diversity by 1.5 times. Also, observation of the defecating condition and gut microflora of 57 healthy persons showed increased diversity index and improvement of the defecating condition after TWX administration. These results suggest that, even if exposed to toxic substances which results in oxidative stress, daily effort of decreasing oxidative stress can improve/prevent their host's diseases by increasing gut bacterial diversity. References: 1. Novel compositions and uses thereof WO 2008071790 A3<br />2. Antioxidant composition and its use in diabetes EP 1932542 A1<br />3. Composition for accelerating alcohol metabolism and for reducing the risk of alcohol induced diseases WO 2012095509 A8<br />4. Composition for moderating triglyceride and cholesterol levels WO 2009062910 A1 |
