Abstract:
Geomaterials and biological tissues have numerous properties in common. Both are naturally evolving porous media, the fluid of both is water, both exhibit large specimen-to-specimen variability of material properties, both are anisotropic, both have microstructure evolving from an intricate communication between environmental conditions and internal physics, both have ionisation along fluid-solid interfaces, and both have numerous ionic species dissolved in the fluid. It is no wonder that myriads of applications on geomechanical models have been found in biology. Many applications include herniation of the intervertebral disc [1,2], tissue differentiation driven by ion-exchange [3-4], swelling at extremely large deformation [5], osteoporosis, osteoarthritis [6], coronary vascular disease as a multiporosity problem [7], mechanotransduction in gel-like tissues [8-9], diffusiophoresis-driven propulsion [10-11]. These applications have led to novel numerical techniques, novel design of prostheses and better understanding of tissue engineering constructs [9].
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2. Wilke H.-J., van Rijsbergen M., Ito K., Huyghe J.M., Brayda-Bruno M., Galbusera F. Ageing and degenerative changes of the intervertebral disc and their impact on spinal flexibility. Eur. Spine J. 23 (S3) : S324-S332 (2014) .
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5. Yu C.,_Malakpoor K. and Huyghe J.M.. A three-dimensional transient mixed hybrid finite element model for swelling hydrogels with strain dependent permeability. Soft Matter14(19): 3834-3848 (2018)
6. Wilson W., Huyghe J.M., van Donkelaar C.C, Depth-dependent compressive equilibrium properties of articular cartilage explained by its composition. Biomech. Mod. Mechanobiol. 6(1-2), 43-53, (2007).
7. J.M. Huyghe. Finite deformation poromechanics, with application to heart muscle and blood perfusion. ALERT Doctoral School 2015. Coupled and Multiphysics phenomena. Ed. By B.A. Schrefler, L. Sanavia, F. Collin, 68-115 (2015)
8. Roos, R.W., Petterson, R., Huyghe, J.M. Confined compression and torsion experiments on a pHEMA gel in various bath concentrations Biomech Mod. Mechobiol. 12: 617-626 (2013).
9. P. Poillot, J.W. Snuggs, C.L. Le Maitre, J. Huyghe. Voltage-Gated Ion Channels in the Intervertebral Disc, abstract presented at the Society for Back Pain Research meeting, September 2019, Sheffield, England, UK.
10. J.M. Huyghe, On the physics underlying longitudinal capillary recruitment, Advances in Experimental Medicine and Biology 1097: 191-200 (2018)
11. J.M. Huyghe, On the physics underlying longitudinal capillary recruitment. In “Molecular, Cellular and Tissue Engineering of the Vascular System”, ed. By B.Fu, N. Wright, Springer Verlag, Berlin (2018).
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