2018 - Sustainable Industrial Processing Summit & Exhibition
4-7 November 2018, Rio Othon Palace, Rio De Janeiro, Brazil
| SILP at SIPS: Combining Pharmaceuticals with Ionic Liquids on Silica-Supports Robin Rogers1; 1UNIVERSITY OF ALABAMA, Tuscaloosa, United States; PAPER: 58/Molten/Plenary (Oral) SCHEDULED: 11:45/Mon./Bossa (150/3rd) ABSTRACT: Ionic Liquids (ILs, salts that melt below 100 °C) loaded on silica have been studied for gas phase reactions, but they have not been used in solution due to the leaching properties of the ILs and the deactivation of the catalyst. One area where the "Supported Ionic Liquid Phase" (SILP) strategy would be a tremendous advantage would be in the loading of ILs that are intended and necessarily leached in order to carry out their functions, as is the case of ILs of Active Pharmaceutical Ingredients (APIs). We have found that IL-APIs are readily loaded and leached from silica, giving to the material a few advantages, including the ability to deliver these liquid salt drugs in solid form as free flowing powders. This presentation will discuss the loading, leaching, and favorable physical and chemical properties exhibited by these IL-APIs in solid form. References: [1] Bica, K.; Rodriguez, H.; Gurau, G.; Cojocaru, O. A.; Riisager, A.; Fehrmann, R.; Rogers, R. D. "Pharmaceutically Active Ionic Liquids with Solids Handling, Enhanced Thermal Stability, and Fast Release," Chem. Commun. 2012, 48, 5422-5424. DOI: 10.1039/C2CC30959A [2] Cojocaru, O. A.; Siriwardana, A.; Gurau, G.; Rogers, R. D. "Pharmaceutically active supported ionic liquid phases," In Supported Ionic Liquids - Fundamentals and Applications, Fehrmann, R., Riisager, A., Haumann, M., Eds.; Wiley-VCH: Weinheim, Germany, 2014; Chapter 19; pp 387-406. ISBN: 978-3-527-32429-3. |
