Synthesis and Catalysis with Ionic Liquids - From Batch to Flow Katharina Schröder (bica)1; 1INSTITUTE OF APPLIED SYNTHETIC CHEMISTRY, Vienna, Austria; PAPER: 352/Molten/Regular (Oral) SCHEDULED: 14:25/Tue./Bossa (150/3rd) ABSTRACT: Despite remarkable developments in ionic liquid technologies with a diverse range of applications, considerably less progress has been made in their preparation. Until today, most hydrophobic prepared in a two-step batch process involves the initial alkylation of an amine or phosphine followed by subsequent metathesis to exchange the anion, a strategy which has already been described in seminal books and reviews on ionic liquids in synthesis in the late 1990s, and has since then remained almost unaltered [1]. Yet a number of critical aspects limits its utility for the large-scale production of hydrophobic ionic liquids in this classical batch process. In parallel to their classical synthesis, the majority of applications of ionic liquids in catalysis is dedicated to batch processes, despite the clear advantages and benefits of a continuous flow set-up.<br />In here, we present novel strategies for the continuous flow production of ionic liquids, aiming for a fast and halide-free approach that eliminates the need of anion metathesis [2]. Critical aspects of an atom efficient continuous-flow synthesis of ionic liquids, but also of their application in catalysis will be discussed. Eventually, advantages and limitations of continuous flow processes will be highlighted, with a number of processes varying from ionic liquid synthesis to their application as reaction media or catalysts in hydrogen or carboxylation reactions either with bulk or supported ionic liquids [3,4]. References: [1] T. Welton and P. Wasserscheid, Ionic Liquids in Synthesis, VCH-Wiley, Weinheim, 2002.<br />[2] K. Bica, M. Schoen, P. Gaertner and M. D. Mihovilovic, Method for producing ionic liquids containing bis(trifluoromethanesulfonyl)imide anions, PCT Int. Appl. (2017), WO 2017112972 A1 20170706<br />[3] J. Bruenig, Z. Csendes, S. Weber, N. Gorgas, R. W. Bittner, A. Limbeck, K. Bica, H. Hoffmann, and Karl Kirchner, ACS Catal. 2018, 8, 1048.<br />[4] A. Sainz Martinez, C. Hauzenberger, A. Ranjan Sahoo, Z. Csendes, H. Hoffmann and K. Bica, ACS Sus. Chem. Eng. 2018, submitted. |