2018 - Sustainable Industrial Processing Summit & Exhibition
4-7 November 2018, Rio Othon Palace, Rio De Janeiro, Brazil
Seven Nobel Laureates have already confirmed their attendance: Prof. Dan Shechtman, Prof. Sir Fraser Stoddart, Prof. Andre Geim, Prof. Thomas Steitz, Prof. Ada Yonath, Prof. Kurt Wüthrich and Prof. Ferid Murad. More than 400 Abstracts Submitted from about 60 Countries.
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    Electrochemical Catalytic Probes for Amplified Biosensing
    Huangxian Ju1;
    1NANJING UNIVERSITY, Nanjing, China;
    PAPER: 103/Electrochemistry/Regular (Oral)
    SCHEDULED: 16:20/Mon./Copacabana B (150/1st)



    ABSTRACT:
    Recently, the investigation on electrochemical biosensing has made great progress. The developed biosensors have extensively been used in different fields, particularly, the sensitive and accurate detection of DNA, protein and metal ions. The designs of specific electrochemical catalytic probes are becoming the main topic of electrochemical biosensing research. This presentation will introduce new electrochemical catalytic probes designed in our group for development of amplified biosensing strategies in last two years. For example, we prepared two electrochemical catalytic probes to design two molecular switches for electrochemical DNA sensing by coupling with porphyrin-encapsulated metal-organic frameworks. Several new signal amplification strategies based on nanotechnology and molecular biology have been presented for DNA detection and immunoassay. By the recognition of nucleic acids to metal ions, some label-free methods have been developed for specific and sensitive detection of heavy metal ions. Some new electrochemiluminescent emitters have been synthesized and used for design of new ECL biosensing mechanisms. A wavelength-resolved ratiometric photoelectrochemical technique has also been developed for sensing applications. These works led to a series of amplified methods for sensitive detection of DNA, microRNA and proteins.

    References:
    [1] H.X. Ju, et al., Biosens. Bioelectron. 79 (2016) 861; 77 (2016) 733; 77 (2016) 557; 85 (2016) 698; 92 (2017) 171; 96 (2017) 8; 100 (2018) 28.
    [2] H.X. Ju, et al., Anal. Chem. 88 (2016) 845; 88 (2016) 8339; 88 (2016) 9856; 88 (2016) 10680; 89 (2017) 7659; 89 (2017) 13480; 90 (2018) 1202; 90 (2018) 1202; 90 (2018) 3703.
    [3] H.X. Ju, et al., Chem. Sci. 7 (2016) 774; Chem. Commun. 52 (2016) 1226; ACS Applied Mater. Interf. 8 (2016) 341; 9 (2017) 27185.