Editors: | F. Kongoli, Z. Wang, T. Okura, E. Souza, A. C. Silva |
Publisher: | Flogen Star OUTREACH |
Publication Year: | 2018 |
Pages: | 256 pages |
ISBN: | 978-1-987820-94-2 |
ISSN: | 2291-1227 (Metals and Materials Processing in a Clean Environment Series) |
This report describes the compositional and structural design strategy of a micro- and mesoporous silica materials mesh for the efficient removal of uremic toxins towards blood purification application. Our investigation gives the results of the syntheses involving nonionic surfactants and tetraethylorthosilicate (TEOS) as silica precursors for the extraction of urea and creatinine from human blood.
The procedure of materials preparation is widely used in the synthesis of mesoporous solids. By using various amounts of non ionic surfactants (Brij S 100 and TRITON X-114) never used before in the synthesis, micro- and mesoporous purely silica samples were obtained. Structural and textural parameters indicated the presence of mesopores interconnected with micropores in a "wormhole-like" or cubic disposition.
Adsorption of urea and creatinine, waste biological molecules, onto silica materials was studied and a drastic diminution of creatinine concentration from blood plasma was observed, by a simple contact at ambient temperature.
The synthesis protocol, the characterization of materials as well as the results of creatinine adsorption are detailed and a discussion is proposed in this work. Micro- and mesoporous silica are convenient for both research and biomedical applications.