2018-Sustainable Industrial Processing Summit
SIPS2018
Volume 6. New and Advanced Materials and Technologies
| Editors: | F. Kongoli, F. Marquis, P. Chen, T. Prikhna, N. Chikhradze |
| Publisher: | Flogen Star OUTREACH |
| Publication Year: | 2018 |
| Pages: | 392 pages |
| ISBN: | 978-1-987820-92-8 |
| ISSN: | 2291-1227 (Metals and Materials Processing in a Clean Environment Series) |
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Magnetoplasmonic Nanoheterodimers for Synergistic Enhancement of Cancer Therapy
Carola Kryschi1; Stefanie Klein2;1FRIEDRICH-ALEXANDER UNIVERSITY ERLANGEN, Erlangen, Germany; 2FRIEDRICH-ALEXANDER UNIVERSITY OD ERLANGEN, Erlangen, Germany;
Type of Paper: Regular
Id Paper: 263
Topic: 43
Abstract:
Our primary research objective is to design magnetically targeting magnetoplasmonic nanoheterodimers as multimodal nanotherapeutics for synergistic cancer therapy. Therefore, superparamagnetic iron oxide nanoparticles (SPIONs) were merged with gold nanospheres, nanoclusters, or nanopatches, either through a thermal decomposition procedure or via a facile coprecipitation synthesis. SPIONs with sizes around 20 nm were shown to feature superparamagnetism as well as perform an enormous capacity as X-ray dosage enhancer when internalized by tumor cells [1,2]. The Au-SPION nanoheterodimers combine high-Z material with catalytically active Fe<sub>3</sub>O<sub>4</sub> surfaces and moreover, plasmonic properties with superparamagnetic performance [3]. The X-ray enhancing effect was demonstrated to be increased by endowing the Au and Fe<sub>3</sub>O<sub>4</sub> surfaces with charged and distinctly, specifically acting chemical moieties as being for instance, nitrosyl tetrafluoroborate and S-nitroso glutathione. We could substantiate synergistic interactions between X-ray exposed Au and SPION surfaces, which were manifest by the simultaneous production of the nitric oxide radical at the SPION surface and the superoxide radical at the Au surface. The surface-confined reaction between these radicals generated peroxynitrite. This highly reactive species may cause nitration of mitochondrial proteins, lipid peroxidation, and induces DNA strand breaks. Therefore, high concentrations of peroxynitrite are expected to give rise to severe cellular energetic derangements and thereupon, entail rapid cell death.
Keywords:
Advanced materials; Catalysis; Oxidation; Surface reactivity;References:
[1] S. Klein, A. Sommer, L.V.R. Distel, W. Neuhuber, C. Kryschi, Biochem. Biophys. Res. Commun. 61 (2012) 290-302.[2] S. Klein, M. Kızaloğlu, L. Portilla, H. Park, T. Rejek, J. Hümmer, K. Meyer, R. Hock, L. V. R. Distel, M. Halik, C. Kryschi, Small (2018) 1704111.
[3] S. Klein, C. Harreiss, C. Menter, J. Hümmer, L. Distel, K. Meyer, R. Hock, C. Kryschi, ACS Applied Materials & Interfaces (2018) in print.