2014-Sustainable Industrial Processing Summit
SIPS 2014 Volume 5: Composite, Ceramic, Quasi-crystals, Nanomaterials & Coatings
| Editors: | Kongoli F |
| Publisher: | Flogen Star OUTREACH |
| Publication Year: | 2014 |
| Pages: | 578 pages |
| ISBN: | 978-1-987820-07-2 |
| ISSN: | 2291-1227 (Metals and Materials Processing in a Clean Environment Series) |
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Anticancer drug-loaded Plasmonic core-shell Nanocapsules for targeted cancer therapy
Pankaj Thakur1;1ITALIAN INSTITUTE OF TECHNOLOGY, Naples, Italy;
Type of Paper: Regular
Id Paper: 246
Topic: 14
Abstract:
In the past five years, nanoshell-based photothermal cancer therapy has been realized, and the transition from bench to bedside for this potentially revolutionary approach has begun [1]. Cancer is still amongst the major causes of death in the developed world [2]. The selective delivery of anticancer agents is important in order to suppress their systemic distribution and ensuing undesirable side-effects [3]. Conventional cancer chemotherapy is often ineffective and associated with serious side-effects. In order to overcome the problems associated with conventional chemotherapy, extensive research is being performed on the development of anticancer drug carriers which would be able to selectively deliver their drug-load to cancer cells. In the light of the present work, the gold has to functionalize with a copolymer which will provide antibiofouling characteristic to the nanoparticles and will allow for drug (e.g. daunorubicin, doxorubicin etc) conjugation. These multifunctional drug nanocarriers will represent a significant step towards the development of safe and effective cancer treatment modalities. In the context of this work, multifunctional magnetic-core gold-shell nanoparticles will be developed and their comparative potential in comparison to another anti-cancer agent (non-antibiotic) will be studied. By a thermolytic process, syntheses of magnetic nanocrystals (the magnetic core) have been carried out and coating of the magnetic nanocrystals by a thin polymer layer is under process [4]. Along with the above methodology the Polymer based Nanocapsules are also being explored in the ensuing study.
References
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[2] A. Jemal, R.Siegel, E.Ward, Y. Hao, J. Xu, M. J. Thun, 2009, 225-249.
[3] R. Duncan 2006, 6, 688.
[4] H. Wang, D.W. Brandl, F. Le, P. Nordlander, N. J. Halas, Nano Lett. 2006, 6, 827.